Molecular Genetics of Recombination

  • Andrés Aguilera
  • Rodney Rothstein

Part of the Topics in Current Genetics book series (TCG, volume 17)

Table of contents

  1. Front Matter
    Pages I-XXIV
  2. Bénédicte Michel, Zeynep Baharoglu, Roxane Lestini
    Pages 1-26
  3. Bénédicte Michel, Zeynep Baharoglu, Roxane Lestini
    Pages 1-26
  4. Humberto Sanchez, Begoña Carrasco, Silvia Ayora, Juan C. Alonso
    Pages 27-52
  5. Humberto Sanchez, Begoña Carrasco, Silvia Ayora, Juan C. Alonso
    Pages 27-52
  6. Benoit Arcangioli, Laura Roseaulin, Allyson Holmes
    Pages 95-133
  7. Wolf-Dietrich Heyer
    Pages 95-133
  8. Wolf-Dietrich Heyer
    Pages 95-133
  9. Hannah L. Klein
    Pages 135-167
  10. Hannah L. Klein
    Pages 135-167
  11. Matthew C. Whitby
    Pages 169-199
  12. Dana Branzei, Marco Foiani
    Pages 201-219
  13. Matthew C. Whitby
    Pages 221-249
  14. Felipe Cortés-Ledesma, Félix Prado, Andrés Aguilera
    Pages 221-249
  15. Benoit Arcangioli, Laura Roseaulin, Allyson Holmes
    Pages 251-283
  16. Michael Lisby, Rodney Rothstein
    Pages 317-333

About this book

Introduction

Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.

Keywords

DNA Double-strand break Repair Escherichia coli Genome Instability biochemistry cell biology conservation genetics metabolism protein proteins recombination regulation saccharomyces cerevisiae transcription

Editors and affiliations

  • Andrés Aguilera
    • 1
  • Rodney Rothstein
    • 2
  1. 1.Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMERCSIC-Universidad de SevillaSevillaSpain
  2. 2.Department of Genetics & DevelopmentColumbia University Medical CenterNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-71021-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-71020-2
  • Online ISBN 978-3-540-71021-9
  • Series Print ISSN 1610-2096
  • Series Online ISSN 1610-6970
  • About this book
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