Skip to main content

Medicinal Properties of Organometallic Compounds

  • Chapter
  • First Online:
Bioorganometallic Chemistry

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 17))

Abstract

Although organometallic compounds are ubiquitous in nature, synthetic organometallic compounds are generally considered to be toxic or non-compatible with biological systems. Despite this perception the medicinal properties of organometallic compounds, in particular organo-transition metal compounds, have been probed for a long time and in the last few years the area has grown considerably. In this chapter the medicinal properties of organometallic compounds are reviewed, with notable applications in the treatment and diagnosis of cancer and in the treatment of viral, fungal, bacterial and parasitic infections.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albert A (1985) Selective Toxicity, 7th Ed. Chapman and Hall, New York, p 206

    Google Scholar 

  2. Rosenberg B, VanCamp L, Krigas T (1965) Nature 205:698

    CAS  Google Scholar 

  3. Reedijk J (1996) Chem Commun :801

    Google Scholar 

  4. Wong E, Giandomenico CM (1999) Chem Rev 99:2451therein

    CAS  Google Scholar 

  5. Sava G, Alessio E, Bergamo A, Mestroni G (1999) In: Clarke MJ, Sadler PJ (eds) Metallopharmaceuticals I, DNA Interactions. Springer-Verlag, Berlin Heidelberg, p 143

    Google Scholar 

  6. Takahara PM, Frederick CA, Lippard SJ (1996) J Am Chem Soc 118:12309

    CAS  Google Scholar 

  7. Farrell N, Kelland LR, Roberts JD, Van Beusichem M (1992) Cancer Res 52:5065

    CAS  Google Scholar 

  8. Zou Y, Houten B, Farrell N (1993) Biochemistry 32:547

    Google Scholar 

  9. Navarro M, Pérez H, Sánchez-Delgado RA (1997) J Med Chem 40:1937

    CAS  Google Scholar 

  10. Martell AE, Hancock RD (1996) In: Fackler JP (ed) Modern Inorganic Chemistry. Plenum, New York

    Google Scholar 

  11. Howard-Lock HH, Lock CJL (1987) In: Wilkinson G (ed) Comprehensive Coordination Chemistry. Pergamon, Oxford

    Google Scholar 

  12. Hughes MN (1987) In: Wilkinson G (ed) Comprehensive Coordination Chemistry. Pergamon, Oxford

    Google Scholar 

  13. Bertini I, Gray HB, Lippard SJ, Valentine JS (1994) Bioinorganic Chemistry. University Science Books, Mill Valley, CA, p 505

    Google Scholar 

  14. Dhubhghaill OMN, Sadler PJ (1991) Struct Bond 78:129

    Google Scholar 

  15. Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Giu QY, Zhu J, Tang W, Sun GL, Yang KQ, Chen Y, Zhou L, Fang ZW, Wang YT, Ma J, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY (1997) Blood 89:3354

    CAS  Google Scholar 

  16. Clemow PR, Lowry JW (1954) J Pharm Pharmacol 6:610

    CAS  Google Scholar 

  17. Perrenoud D, Gallezot D, Van Melle G (2001) Contact Dermatology 45:134

    CAS  Google Scholar 

  18. Bleyer AJ (2003) Expert Opin Pharmacol 4:941

    CAS  Google Scholar 

  19. Sengupta P, Mukherjee AM, Chatterjee A (1961) J Ind Med Assoc 37:585

    CAS  Google Scholar 

  20. Gellhorn A, Vandyke HB (1946) J Pharmacol Exp Ther 88:162

    CAS  Google Scholar 

  21. Vanson JAM, Julsurd PR, Hagler DJ, Sim EKW, Puga FJ, Schaff HV, Danielson GK (1994) Ann Thorac Surg 57:604

    Article  CAS  Google Scholar 

  22. Shorvon P, Lamb G (1994) Curr Opin Gastroenterol 10:163

    Google Scholar 

  23. Briand GG, Burford N (1999) Chem Rev 99:2601

    CAS  Google Scholar 

  24. Paris J, Merveill P (1968) Lille Med 13:1038

    Google Scholar 

  25. Degros R (1977) Int J Dermatol 16:391

    Google Scholar 

  26. Lin CY, Shen YH, Wu SH, Lin CH, Hwang SM, Tsai YC (2004) Biochem Biophys Res Commun 315:830

    CAS  Google Scholar 

  27. Green MA (1987) Nucl Med Biol 14:58

    Google Scholar 

  28. Allan CC, Archibald SJ, Silversides JD, Lewis EA (2003) J Inorg Biochem 96:91

    Google Scholar 

  29. Benites PJ, Holmberg RC, Rawat DS, Kraft BJ, Klein LJ, Peters DG, Thorp HH, Zaleski JM (2003) J Am Chem Soc 125:6434

    CAS  Google Scholar 

  30. Sarkar B (1999) Chem Rev 99:2535

    CAS  Google Scholar 

  31. Macke H (1991) Schweiz Med Wochenschr 121:299

    CAS  Google Scholar 

  32. Schachter S, Nelson RW, Kirk CA (2001) J Vet Intern Med 15:379

    CAS  Google Scholar 

  33. Pertuiset B, Visot A, Metzger J (1976) Acta Neurochir 34:151

    CAS  Google Scholar 

  34. Vaillant G, Bertrand A, Nouel JP (1975) J Radiol Electrol Med Nucl 56:380

    Google Scholar 

  35. Truhaut R, Renault H, Claude JR, Rudler M (1975) Ann Biol Clin 33:201

    Google Scholar 

  36. Jin L, Yang, P (1997) Polyhedron 16:3395

    CAS  Google Scholar 

  37. Bellet M, Labat JP, Barthele L, Bellet M (1974) J Radiol Electrol Med Nucl 55:535

    Google Scholar 

  38. Hamblin MR, Newman EL (1994) J Photochem Photobiol B-Biol 26:45

    CAS  Google Scholar 

  39. Bates JN, Baker MT, Guerra R, Harrison DG (1991) Biochem Pharmac 42:S157

    CAS  Google Scholar 

  40. Manukhina EB, Malyshev IY, Malenyuk EB, Zenina TA, Podkidyshev DA, Mikoyan VD, Kubrina LN, Vanin AF (1998) Bull Exp Biol Med 125:23

    CAS  Google Scholar 

  41. Vanin AF, Kleshchev AL, Mordvintsev PI, Sedov KR (1985) Dokl Akad Nauk SSSR 281:742

    CAS  Google Scholar 

  42. Hergesell O, Ritz E (1999) Nephrol Dial Transplant 14:863

    CAS  Google Scholar 

  43. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Chem Rev 99:2293

    CAS  Google Scholar 

  44. Ledermann HP, Morrison WB, Schweitzer ME (2003) Radiology 227:305

    Google Scholar 

  45. Bozzao A, Floris R, Fasoli F, Fantozzi LM, Colonnese C, Simonetti G (2003) Eur Radiol 13:592

    Google Scholar 

  46. Assassa GS, Siegel ME, Chen DCP, Ansari A (1994) Clin Nucl Med 19:614

    CAS  Google Scholar 

  47. Collery P, Keppler BK, Madoulet C, Desoize B (2002) Crit Rev Oncol Hematol 42:283

    Google Scholar 

  48. Jao SW, Lee W, Ho YS (1990) Dis Colon Rectum 33:99

    CAS  Google Scholar 

  49. Howard-Lock HH, Lock CGL (1987) In: Wilkinson G (ed) Comprehensive Coordination Chemistry. Pergamon, Oxford, p 755

    Google Scholar 

  50. Okatani Y (1980) J Asthma Res 17:165

    CAS  Google Scholar 

  51. Van Arsdel PP (1981) J Allergy Clin Immunol 67:348

    Google Scholar 

  52. Muranaka M, Nakajima K, Suzuki S (1981) J Allergy Clin Immunol 67:350

    CAS  Google Scholar 

  53. Shaw CF (1999) Chem Rev 99:2589

    CAS  Google Scholar 

  54. Agrawal KC, Bears KB, Marcus D, Jonassen HB (1978) Proc Am Assoc Cancer Res 69:110

    Google Scholar 

  55. Simon TM, Kunishima DH, Vibert GJ, Lorber A (1979) Cancer 44:1965

    CAS  Google Scholar 

  56. Okada T, Patterson BK, Ye S-Q, Gurney ME (1993) Virology 192:631

    CAS  Google Scholar 

  57. Tepperman K, Shinju Y, Roy PW, Floyd R, Zhao Z, Dorsey J, Elder RC (1994) Met Based Drugs 1:433

    CAS  Google Scholar 

  58. Shapio DL, Masci JR (1996) J Rheumatol 23:1818

    Google Scholar 

  59. Louw WKA, Dormehl IC, van Rensburg AJ, Hugo N, Alberts AS, Forsyth OE, Beverley G, Sweetlove MA, Marais J, Lotter MG, van Aswegen A (1996) Nucl Med Biol 23:935

    CAS  Google Scholar 

  60. Schettino CJ, Kramer EL, Noz ME, Taneja S, Padmanabhan P, Lepor H (2004) Am J Roentgenol 183:519

    Google Scholar 

  61. Nakajima S, Yamauchi H, Sakata I, Hayashi H, Yamazaki K, Maeda T, Kubo Y, Samejima N, Takemura T (1993) Nucl Med Biol 29:231

    Google Scholar 

  62. Moder KP (1996) Expert Opin Ther Pat 6:29

    CAS  Google Scholar 

  63. Birch NJ (1999) Chem Rev 99:2659

    CAS  Google Scholar 

  64. Armstrong J, Beidas AS, Craik DJ, Stephenson WH (1955) J Pharm Pharmacol 7:862

    CAS  Google Scholar 

  65. Morniere P, Maurouard C, Boudailliez B, Westeel PF, Achard JM, Boitte F, Elesper N, Compagnon M, Maurel G, Bouillon R, Pamphile R, Fournier A (1992) Nephron 60:154

    Article  CAS  Google Scholar 

  66. Kinnunen O, Salokannel J (1987) Ann Clin Res 19:321

    CAS  Google Scholar 

  67. Kinnunen O, Karppanen H, Salokannel J (1989) Magnesium Bull 11:68

    Google Scholar 

  68. Takehara Y, Sakahara H, Masunaga H, Isogai S, Kodaira N, Sugiyama M, Takeda H, Saga T, Nakajima S, Sakata I (2002) Magn Reson Med 47:549

    CAS  Google Scholar 

  69. Zhou R, Balasubramanian SV, Kahl SB, Straubinger RM (1999) J Pharm Sci 88:912

    CAS  Google Scholar 

  70. Pitts RF, Kessler RH, Lozano R (1957) Science 125:750

    Google Scholar 

  71. Milnor JP (1950) Proc Soc Exp Biol Med 75:63

    CAS  Google Scholar 

  72. Overman WJ, Gordon WH, Burch GE (1950) Circulation 1:496

    Google Scholar 

  73. Porzi G, Minellibertazzoni E (1975) Boll Soc Ital Biol Sper 51:1591

    CAS  Google Scholar 

  74. Sartin JS, Perry HO (1995) J Am Acad Dermatol 32:255

    CAS  Google Scholar 

  75. Ventura HO, Mehra MR, Young JB (2001) J Card Fail 7:277

    CAS  Google Scholar 

  76. Borle F, Radu A, Fontolliet C, van den Bergh H, Monnier P, Wagnieres G (2003) Br J Cancer 89:2320

    CAS  Google Scholar 

  77. Peschel RE, Colberg JW, Chen Z, Nath R, Wilson LD (2004) Cancer J 10:170

    Article  CAS  Google Scholar 

  78. Bruno G, Cusumano M, Giannetto A, Zappala M, Nicolo F, Romeo R (1997) J Inorg Biochem 65:97

    CAS  Google Scholar 

  79. Brunner H, Obermeier H, Szeimies RM (1995) Chem Berichte 128:173

    CAS  Google Scholar 

  80. Desoize B, Madoulet C (2002) Crit Rev Oncol Hematol 42:317

    Google Scholar 

  81. Gumus F, Pamuk I, Ozden T, Yildiz S, Diril N, Oksuzoglu E, Gur S, Ozkul A (2003) J Inorg Biochem 94:255

    CAS  Google Scholar 

  82. Margiotta N, Fanizzi FP, Kobe J, Natile G (2001) Eur J Inorg Chem 1303

    Google Scholar 

  83. Rodriguez-Cabezas MN, Mesa-Valle CM, Azzouz S, Moraleda-Lindez V, Craciunescu D, Gutierrez-Rios MT, De Frutos MI, Osuna A (2001) Pharmacology 63:112

    CAS  Google Scholar 

  84. Powell NA, Hill AM, Levason W, Webster M (1996) J Chem Soc Dalton 467

    Google Scholar 

  85. Bien M, Pruchnik FP, Seniuk A, Lachowicz TM, Jakimowicz P (1999) J Inorg Biochem 73:49

    CAS  Google Scholar 

  86. Sanchez-Delgado RA, Navarro M, Perez H, Urbina JA (1996) J Med Chem 39:1095

    CAS  Google Scholar 

  87. Sava G, Bergamo A (2000) Int J Oncol 17:353

    CAS  Google Scholar 

  88. Otero L, Noblia P, Gambino D, Cerecetto H, Gonzalez M, Ellena JA, Piro OE (2003) Inorg Chim Acta 344:85

    CAS  Google Scholar 

  89. Anderberg PI, Harding MM, Luck IJ, Turner P (2002) Inorg Chem 41:1365

    CAS  Google Scholar 

  90. Morbidelli L, Donnini S, Filippi S, Messori L, Piccioli F, Orioli P, Sava G, Ziche M (2003) Brit J Cancer 88:1484

    CAS  Google Scholar 

  91. Maurya MR, Unny IR, Alekar NA, Gopinathan S, Gopinathan C (1997) Indian J Chem Sect A – Inorg Bio-Inorg Phys Theor Anal Chem 36:1058

    Google Scholar 

  92. Kohlickova M, Jedinakova-Krizova V, Melichar F (2000) Chem Listy 94:151

    CAS  Google Scholar 

  93. Silver S (2003) FEMS Microbiol Rev 27:369

    Google Scholar 

  94. Ford MM (2004) Vet Clin N Am-Small 34:669

    Google Scholar 

  95. Singal A, Thami GP (2003) J Dermatol 30:644

    CAS  Google Scholar 

  96. Piva JR, Canal AM, Piva CE, Reus V, Salvetti NR, Ortega HH (2003) J Histotechnol 26:31

    Google Scholar 

  97. Bijwaard H, Brugmans MJP, Leenhouts HR (2004) Radiat Res 162:171

    CAS  Google Scholar 

  98. Wang RF, Zhang CL, Zhu SL, Zhu M (2003) Med Princ Pract 12:97

    Google Scholar 

  99. Vanlic-Razumenic N (1999) J Radioanal Nucl Chem 242:235

    CAS  Google Scholar 

  100. McCaughan JS (1999) Drug Aging 15:49

    CAS  Google Scholar 

  101. Tomura N, Watanabe O, Omachi K, Sakuma I, Takahashi S, Otani T, Kidani H, Watarai J (2004) Eur Radiol 14:1249

    Google Scholar 

  102. Liu S, Edwards DS (1999) Chem Rev 99:2235

    CAS  Google Scholar 

  103. Arano Y (2002) Ann Nucl Med 16:79

    CAS  Google Scholar 

  104. Thompson KH, McNeill JH, Orvig C (1999) Chem Rev 99:2562

    Google Scholar 

  105. Milowsky MI, Nanus DM, Kostakoglu L, Vallabhajosula S, Goldsmith SJ, Bander NH (2004) J Clin Oncol 22:2522

    CAS  Google Scholar 

  106. Tsimberidou AM, Murray JL, O'Brien S, Wierda WG, Keating MJ (2004) Cancer 100:2195

    CAS  Google Scholar 

  107. Konan YN, Gurny R, Allemann E (2002) J Photochem Photobiol B 66:89

    CAS  Google Scholar 

  108. Sparsa A, Bonnetblanc JM (2004) Ann Dermatol Vener 131:255

    CAS  Google Scholar 

  109. Bhowon MG, Laulloo BSJ (2004) Indian J Chem Sect A – Inorg Bio-Inorg Phys Theor Anal Chem 43:1131

    Google Scholar 

  110. http://www.ncirs.usyd.edu.au/facts/f-thiomersal.html

  111. Garrett CE, Prasad K (2004) Adv Synth Catal 346:889

    CAS  Google Scholar 

  112. Templeton DM, Fresen J (1999) Anal Chem 363:505

    CAS  Google Scholar 

  113. Edwards EI, Epton R, Marr G (1975) J Organometal Chem 85:C23

    CAS  Google Scholar 

  114. Sturchler D (1989) Parasitol Today 5:39

    Google Scholar 

  115. Muller R, Baker JR (1990) Medical Parasitology. Gower Medical Publishing, London

    Google Scholar 

  116. Veignie E, Moreau S (1991) Ann Trop Med Parasitol 85:229

    CAS  Google Scholar 

  117. Krogstad DJ, Gluyman IZ, Herwaldt BL, Schlesinger PH, Wellems TE (1987) Am J Trop Med Hyg 36:213

    CAS  Google Scholar 

  118. Slater A, Swiggard W, Orton B, Flitter W, Goldberg D, Cerami A, Henderson G (1991) Proc Natl Acad Sci USA 88:325

    CAS  Google Scholar 

  119. Ling V, Thompson LH (1974) Proc Natl Acad Sci Cell Physiol 83:103

    CAS  Google Scholar 

  120. Slater AF, Cerami A (1992) Nature 355:167

    CAS  Google Scholar 

  121. Bendrat K, Berger B, Cerami A (1995) Nature 378:138

    CAS  Google Scholar 

  122. Ridley R, Dorn A, Matile H, Kansy M (1995) Nature 378:138

    CAS  Google Scholar 

  123. Wernsdorfer W, McGregor I (eds) (1988) Malaria: Principles and Practice of Malariology. Churchill Livingstone New York, p 1818

    Google Scholar 

  124. Fitch C, Chevli R, Banyal H, Phillips G, Pfallar M, Krogstad D (1982) Antimicrob Agents Chemother 21:819

    CAS  Google Scholar 

  125. Sanchez C, Wunsch S, Lanzer M (1997) J Biol Chem 272:2652

    CAS  Google Scholar 

  126. Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, Milhous WK, Schlesinger PH (1987) Science 283:1283

    Google Scholar 

  127. Biot C, Glorian G, Maciejewski L, Brocard J (1997) J Med Chem 40:3715

    CAS  Google Scholar 

  128. Domarle O, Blampain G, Agnaneit H, Nzadiyabi T, Lebibi J, Brocard J, Maciejewski L, Biot C, Georges A, Millet P (1998) Antimicrob Agents Chemother 42:540

    CAS  Google Scholar 

  129. Croft S (1988) Trends Pharmacol Sci 9:376

    CAS  Google Scholar 

  130. Berman J (1988) J Infect Dis 10:560

    CAS  Google Scholar 

  131. Ashford R, Desjeux P, de Raadt P (1992) Parasitol Today 8:104

    CAS  Google Scholar 

  132. Ouellette M, Papadopoulou B (1993) Parasitol Today 9:150

    CAS  Google Scholar 

  133. Loiseau PM, Craciunescu DG, Doadriovillarejo JC, Certadfombona G, Gayral P (1992) Tropical medicine and parasitology 43:110

    CAS  Google Scholar 

  134. Zinsstag J, Brun R, Craciunescu DG, Iglesias EP (1991) Tropical medicine and parasitology 42:41

    CAS  Google Scholar 

  135. Mesa Valle CM, Moraleda Lindez V, Craciunescu D, Alonso M, Osuna A (1993) Arzneimittel Forsch/Drug Res 43:1010

    CAS  Google Scholar 

  136. Loiseau PM, Dreyfuss G, Doadrio L, Parrondo E, Craciunescu DG (2001) J Chemother 13:59

    CAS  Google Scholar 

  137. Loiseau PM, Reyfuss G, Daulouède S, Lachâtre G, Vincendaeu P, Craciunescu DG (1997) Trop Med Int Health 2:19

    CAS  Google Scholar 

  138. Loiseau PM, Jaffe JJ, Craciunescu DG (1998) Int J Parasitol 28:1279

    CAS  Google Scholar 

  139. Loiseau PM, Mbongo N, Bories C, Boulard Y, Craciunescu DG (2000) Parasite 7:103

    CAS  Google Scholar 

  140. Mbongo N, Loiseau PM, Lawerence F, Craciunescu DG, Iglesias EP (1991) Tropical medicine and parasitology 42:41

    Google Scholar 

  141. Castilla JJ, Mesa Valle CM, Sanchez Moreno M, Arnedo T, Rosales MJ, Mascaro C, Crraciunescu D, Osuna A (1996) Arzneimittel-forschung-drug research 46:990

    CAS  Google Scholar 

  142. Craciunescu DG, Scarcia V, Furlani A, Papaioannou A, Parrondo Iglesias E, Alonso MP (1991) In Vivo 5:329

    CAS  Google Scholar 

  143. Craciunescu G, Scarcia V, Furlani A, Parrondo Iglesias E, Ghirvu C, Papaioannou A (1989) Anticancer Res 9:781

    CAS  Google Scholar 

  144. Piwnicaworms D, Rao VV, Kronauge JF, Croop JM (1995) Biochemistry 34:12210

    CAS  Google Scholar 

  145. Rao VV, Herman LW, Kronauge JF, Piwnica-Worms D (1998) Nucl Med Biol 25:225

    CAS  Google Scholar 

  146. D'Cruz OJ, Waurzyniak B, Uckum FM (2004) Antiomicrobial agents and chemotherapy 48:1082

    Google Scholar 

  147. D'Cruz OJ, Waurzyniak B, Uckum FM (2001) Contraception 64:177

    Google Scholar 

  148. Allardyce CS, Dyson PJ (2001) J Cluster Sci 12:563

    CAS  Google Scholar 

  149. Crowe AJ, Smith PJ, Atassi G (1980) Chem-Biol Interact 32:171

    CAS  Google Scholar 

  150. Crowe AJ, Smith PJ, Atassi G (1984) Inorg Chim Acta 93:179

    CAS  Google Scholar 

  151. Han GY, Yang P (2002) J Inorg Biochem 91:230

    CAS  Google Scholar 

  152. Triolo F, Pellerito C, Stocco GC, Fiore T, Aggio F, Pellerito L, Triolo R (1999) Appl Organomet Chem 13:733

    CAS  Google Scholar 

  153. Barbieri R, Silvestri A (1991) J Inorg Biochem 41:31

    CAS  Google Scholar 

  154. Bollo E, Ceppa L, Cornaglia E, Nebbia C, Biolatti B, Dacasto M (1996) Hum Exp Toxicol 15:219

    Article  CAS  Google Scholar 

  155. Boualam M, Willem R, Biesemans M, Gielen M (1991) Appl Organomet Chem 5:497

    CAS  Google Scholar 

  156. Buckley RG, Elsome AM, Fricker SP, Henderson GR, Theobald BR, Parish RV, Howe BP, Kelland LR (1996) J Med Chem 39:5208

    CAS  Google Scholar 

  157. Marcon G, Carotti S, Coronnello M, Messori L, Mini E, Orioli P, Mazzei T, Agostina Cinellu M, Minghetti G (2002) J Med Chem 45:1672

    CAS  Google Scholar 

  158. Pratviel G, Bernadou J, Meunier B (1995) Angew Chem Int Ed 34:746

    CAS  Google Scholar 

  159. Vol'pin M, Levitin I, Osinsky S (1996) Angew Chem Int Ed 35:2395

    Google Scholar 

  160. Bakac A, Espenson JH (1989) Inorg Chem 28:3901

    CAS  Google Scholar 

  161. Riodan CG, Wei P (1994) J Am Chem Soc 116:2189

    Google Scholar 

  162. Keppler BK, Vogel EA (1993) In: Pinedo HM, Schronagel JH (eds) Platinum and other metal coordination compounds in cancer chemotherapy 2. Plenum, New York, p 253

    Google Scholar 

  163. Hubel R, Polborn K, Knizek J, Noth H, Beck W (2000) Zeitschrift für anorganische und allgemeine Chemie 626:1701

    CAS  Google Scholar 

  164. Popova LV, Babin VN, Belousov YA, Nekrasov YS, Snegireva AE, Borodina NP, Shaposhnikova GM, Bychenko OB, Raevskii PM (1993) Appl Organomet Chem 7:85

    CAS  Google Scholar 

  165. Koepf-Maier P, Koepf H, Neuse EW (1984) J Cancer Res Clin 108:336

    Article  CAS  Google Scholar 

  166. Henderson W, Alley SR (2001) Inorg Chim Acta 322:106

    CAS  Google Scholar 

  167. Top S, Vessières A, Cabestaing C, Laios I, Leclercq G, Provot C, Jaouen G (2001) J Organomet Chem 637:500

    Google Scholar 

  168. Jaouen G, Top S, Vessieres A, Leclercq G, Quivy J, Jin L, Croisy A (2000) CR Acad Sci Ic 3:89

    CAS  Google Scholar 

  169. Rosenfeld A, Blum J, Gibson D, Ramu A (1992) Inorg Chim Acta 201:219

    CAS  Google Scholar 

  170. Viotte M, Gautheron B, Kubicki MM, Nifant'ev IE, Fricker SP (1995) Met Based Drugs 2:311

    CAS  Google Scholar 

  171. Liu R-C, Ma Y-Q, Yu L, Li J-S, Cui J-R, Wang R-Q (2003) Appl Organomet Chem 17:662

    CAS  Google Scholar 

  172. Koepf-Maier P, Klapoetke T (1992) Cancer Res Clin 118:216

    CAS  Google Scholar 

  173. Koepf-Maier P, Klapoetke T (1992) Cancer Chemoth Pharm 29:361

    CAS  Google Scholar 

  174. Koepf-Maier P, Koepf H (1987) Chem Rev 87:1137

    CAS  Google Scholar 

  175. Koepf-Maier P, Neuse E, Klapoetke T, Koepf H (1989) Cancer Chemoth Pharm 24:23

    CAS  Google Scholar 

  176. Ghosh P, D'Cruz OJ, Narla RK, Uckun FM (2000) Clin Cancer Res 6:1536

    CAS  Google Scholar 

  177. Caruso F, Rossi M (2004) Mini Revs Med Chem 4:159

    Google Scholar 

  178. Bernard J, Ortner K, Spingler B, Pietzsch H-J, Alberto R (2003) Inorg Chem 42:1014

    CAS  Google Scholar 

  179. Moksi G, Harding MM (2001) J Inorg Biochem 86:611

    Google Scholar 

  180. Waern JB, Harding MM (2004) Inorg Chem 43:206

    CAS  Google Scholar 

  181. Guo ML, Sun HZ, McArdle HJ, Gambling L, Sadler PJ (2000) Biochemistry 39:10023

    CAS  Google Scholar 

  182. Köpf H, Köpf-Maier P (1979) Angew Chemie 91:509

    Google Scholar 

  183. Clarke MJ, Zhu FC, Frasca DR (1999) Chem Rev 99:2511

    CAS  Google Scholar 

  184. Sava G, Bergamo A (2000) Int J Oncol 17:353

    CAS  Google Scholar 

  185. Clarke MJ, Galang RD, Rodriguez VM, Kumar R, Pell S, Bryan DM (1988) In: Nicolini M (ed) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Martinus Nijhoff, Boston, p 582

    Google Scholar 

  186. Dale LD, Tocher JH, Dyson TMD, Edwards I, Tocher DA (1992) Anti-Cancer Drug Design 7:3

    CAS  Google Scholar 

  187. Allardyce CS, Dyson PJ, Ellis DJ, Heath SL (2001) Chem Commun 1396

    Google Scholar 

  188. Allardyce CS, Dyson PJ, Ellis DJ, Salter PA, Scopelliti R (2003) J Organomet Chem 668:35

    CAS  Google Scholar 

  189. Gopal YNV, Jayaraju D, Kondapi AK (1999) Biochemistry 38:4382

    CAS  Google Scholar 

  190. Gopal YNV, Konuru N, Kondapi AK (2002) Arch Biochem Biophys 401:53

    CAS  Google Scholar 

  191. Morris RE, Aird RE, Murdoch PDS, Chen H, Cummings J, Hughes ND, Parsons S, Parkin A, Boyd G, Jodrell DI, Sadler PJ (2001) J Med Chem 44:3616

    CAS  Google Scholar 

  192. Akbayeva DN, Gonsalvi L, Oberhauser W, Peruzzini M, Vizza F, Brueggeller P, Romerosa A, Sava G, Bergamo A (2003) Chem Commun 264

    Google Scholar 

  193. Huxham LA, Cheu ELS, Patrick BO, James BR (2003) Inorg Chim Acta 352:238

    CAS  Google Scholar 

  194. Pratviel G, Bernadou J, Meunier B (1995) Angew Chem Int Ed 34:746

    CAS  Google Scholar 

  195. Vol'pin M, Levitin I, Osinsky S (1996) Angew Chem Int Ed 35:2395

    Google Scholar 

  196. Grimes RN (2000) Coord Chem Rev 200–202:773

    Google Scholar 

  197. Sülü M, Küçükbay H, Durmaz R, Günel S (1998) Arzneimittel-forschung-drug research 48:291

    Google Scholar 

  198. Çetinkaya B, Özdemir I, Binbaůio~glu B, Durmaz R, Günel S (1999) Arzneimittel-forschung-drug research 49:538

    Google Scholar 

  199. Çetinkaya B, Çetinkaya E, Küçükbay H, Durmaz R (1996) Arzneimittel-forschung-drug research 46:821

    Google Scholar 

  200. Özdemir I, Denizci A, Öztürk HT, Çetinkaya B (2004) Appl Organometal Chem 18:318

    Google Scholar 

  201. Schibli R, Netter M, Scapozza L, Birringer M, Schelling P, Dumas C, Schoch J, Schubiger PA (2003) J Organomet Chem 668:67

    CAS  Google Scholar 

  202. Chohan ZH, Khan KM, Supran CT (2004) Appl Organometal Chem 18:305

    CAS  Google Scholar 

  203. D'Cruz OJ, Waurzyniak B, Uckum FM (2004) Antiomicrobial agents and chemotherapy 48:1082

    Google Scholar 

  204. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ (2002) Circ Res 90:e17

    CAS  Google Scholar 

  205. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, Motterlini R (2003) Circ Res 93:178

    CAS  Google Scholar 

  206. Darensbourg DJ, Klausmeyer KK, Reibenspies JH (1995) Inorg Chem 34:4933

    CAS  Google Scholar 

  207. Darensbourg DJ, Klausmeyer KK, Reibenspies JH (1996) Inorg Chem 35:1529

    CAS  Google Scholar 

  208. Pearson J, Cooke J, Takats J, Jordan RB (1998) J Am Chem Soc 120:1434

    CAS  Google Scholar 

  209. Hughey JL, Bock CR, Meyer TJ (1975) J Am Chem Soc 97:4440

    CAS  Google Scholar 

  210. Tuzel IH (1974) J Clin Pharmacol 14:494

    CAS  Google Scholar 

  211. Hayton TW, Legzdins P, Sharp WB (2002) Chem Rev 102:935

    CAS  Google Scholar 

  212. Craciunescu G, Scarcia V, Furlani A, Parrondo Iglesias E, Ghirvu C, Papaioannou A (1989) Anticancer Res 9:781

    CAS  Google Scholar 

  213. Kothari KK, Pillarsetty NK, Katti KV, Volkert WA (2003) Radiochimica Acta 91:53

    CAS  Google Scholar 

  214. Schibili R, Schubiger PA (2002) Euro J Nucl Med Mol Imaging 29:1529

    Google Scholar 

  215. Alberto R, Schibli R, Waibel R, Abram U, Schubiger AP (1999) Coord Chem Rev 190–192:901

    Google Scholar 

  216. Zobi F, Spingler B, Fox T, Alberto R (2003) Inorg Chem 42:2818

    CAS  Google Scholar 

  217. Schmidt K, Jung M, Keilitz R, Schnurr B, Gust R (2000) Inorg Chim Acta 306:6

    CAS  Google Scholar 

  218. Roth T, Eckert C, Fiebig H-H, Jung M (2002) Anticancer Res 22:2281

    CAS  Google Scholar 

  219. Kothari KK, Pillarsetty NK, Katti KV, Volkert WA (2003) Radiochimica Acta 91:53

    CAS  Google Scholar 

  220. Bernard J, Ortner K, Spingler B, Pietzsch H-J, Alberto R (2003) Inorg Chem 42:1014

    CAS  Google Scholar 

  221. DeRosa MC, Crutchley RJ (2002) Coord Chem Rev 233:351

    Google Scholar 

  222. Bakac A, Espenson JH (1989) Inorg Chem 28:3901

    CAS  Google Scholar 

  223. Riodan CG, Wei P (1994) J Am Chem Soc 116:2189

    Google Scholar 

  224. Giraldi T, Sava G, Mestroni G, Zassinovich G, Stolfa D (1978) Chem-Biol Interact 22:231

    CAS  Google Scholar 

  225. Sava G, Giraldi T, Mestroni G, Zassinovich G (1983) Chem-Biol Interact 45:1

    CAS  Google Scholar 

  226. Zassinovich G, Maestroni G, Camus A (1975) J Organomet Chem 91:379

    CAS  Google Scholar 

  227. Giraldi T, Zassinovich G, Mestroni G (1974) Chem-Biol Interact 9:389

    CAS  Google Scholar 

  228. Sava G, Zorzet S, Pacor S, Mestroni G, Zassinovich G (1989) Cancer Chemoth Pharm 24:302

    CAS  Google Scholar 

  229. Giraldi T, Sava G, Bertoli G, Mestroni G, Zassinovich G (1977) Cancer Res 37:2662

    CAS  Google Scholar 

  230. Buckley RG, Elsome AM, Fricker SP, Henderson GR, Theobald BR, Parish RV, Howe BP, Kelland LR (1996) J Med Chem 39:5208

    CAS  Google Scholar 

  231. Parish RV, Howe BP, Wright JP, Mack J, Pritchard RG, Buckley RG, Elsome AM, Fricker SP (1996) Inorg Chem 35:1659

    CAS  Google Scholar 

  232. Navarro M, Pérez H, Sánchez-Delgado RA (1997) J Med Chem 40:1937

    CAS  Google Scholar 

  233. Shapiro DL, Masci JR (1996) J Rheumatology 23:1818

    CAS  Google Scholar 

  234. Tepperman K, Shinju Y, Roy PW, Floyd R, Zhao Z, Dorsey J, Elder RC (1994) Met Based Drugs 1:433

    CAS  Google Scholar 

  235. Bernstein LR, Reed DE (1998) Pub Int Appl PCT/US97/11220

    Google Scholar 

  236. Dimartino MJ, Lee JC, Badger AM, Murhead KA, Mirabelli CK, Hanna N (1986) J Pharma Exp Thera 236:103

    CAS  Google Scholar 

  237. Slavik M, Elias L, Mrema J, Saiers JH (1982) Drug Exp Clin Res 8:379

    CAS  Google Scholar 

  238. Atteke C, Ndong JMM, Aubouy A, Naciejewski L, Brocard J, Lebibi J, Deloron P (2003) J Antimicrobial Chemotherapy 51:1021

    CAS  Google Scholar 

  239. Mariet F, Brosser P (1991) Pharmaceutica Acta Helvetiae 66:60

    CAS  Google Scholar 

  240. Sweiry JH, Mann GE (1991) Am J Physiol 261:G685

    CAS  Google Scholar 

  241. Oreshkin AE, Myasishcheva NV (1990) B Exp Biol Med 109:957

    Google Scholar 

  242. Schenk BE, Festen HPM, Kuipers EJ, Klinkenberg-Knol EC, Meuwissen SGM (1996) Aliment Pharm Therap 10:541

    CAS  Google Scholar 

  243. Deutsch E, Bushong W, Glavan KA, Elder RC, Sodd VJ, Scholz KL, Fortman DL, Lukes SJ (1981) Science 214:85

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paul J. Dyson .

Editor information

Gérard Simonneaux

Rights and permissions

Reprints and permissions

About this chapter

Cite this chapter

Allardyce, C.S., Dyson, P.J. Medicinal Properties of Organometallic Compounds. In: Simonneaux, G. (eds) Bioorganometallic Chemistry. Topics in Organometallic Chemistry, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_001

Download citation

Publish with us

Policies and ethics