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Table of contents

  1. Front Matter
  2. Philip A. Butler, Bernhard Kräutler
    Pages 1-55
  3. Anne Volbeda, Juan C. Fontecilla-Camps
    Pages 57-82
  4. Gérard Simonneaux, Paul Le Maux
    Pages 83-122
  5. Toshiyuki Moriuchi, Toshikazu Hirao
    Pages 143-175
  6. Claire S. Allardyce, Paul J. Dyson
    Pages 177-210
  7. Back Matter

About this book

Introduction

Bioorganometallic Chemistry has become a mature area of science and is comprehensively covered by leading experts in this book. Naturally occuring bioorganometallic complexes, such as vitamin B12 and recently discovered iron and nickel hydrogenases, including a possible role of the latter in the geochemical theory of the origin of life, are considered. The possible formation of carbene complexes of cytochrome P450 enzymes in various metabolisms of xenobiotics is also discussed. The bioorganometallic chemistry is considered to provide not only organometallic receptors such as polynuclear organometallic macrocycles for biologically interesting molecules but also ferrocene-peptide bioconjugates giving a peptidomimetic basis for protein folding. The medicinal properties of organometallic compounds are reviewed, with notable applications in the treatment and diagnosis of cancer and in the treatment of viral, fungal, bacterial and parasitic infections. Therefore the reader will get a balanced view of this rapidly developing and promising area.

Keywords

Bioorganic Chemistry Catalysis Medicinal Chemistry Organometallic chemistry biology chemistry enzymes infections metabolism

Bibliographic information

  • DOI https://doi.org/10.1007/b97910
  • Copyright Information Springer-Verlag Berlin Heidelberg 2006
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-540-33047-9
  • Online ISBN 978-3-540-33049-3
  • Series Print ISSN 1436-6002
  • Series Online ISSN 1616-8534
  • Buy this book on publisher's site
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