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Autocrine Growth Factor Signaling in Motility

  • Chapter
Cell Motility in Cancer Invasion and Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 8))

Abstract

The objective of this chapter is to summarize our current understanding of the role of growth factor autocrine signaling in cell motility. The Epidermal Growth Factor Receptor (EGFR) was chosen as a central example system for motivating autocrine operation as important in both normal physiological processes as well as pathological conditions such as cancer. We provide specific evidence from research literature for autocrine stimulation of cell motility measured in vitro, from several cell lines, and in vivo from mouse models. Relevant growth factors include the EGFR ligands TGF-alpha, HB-EGF, and Amphiregulin, as well as members of other growth factor families including FGF, G-CSF, GM-CSF, HGF and VEGF. Results from autocrine systems that involve EGFR crosstalk are also discussed, including GPCR and IL-6 mediated activation. We outline the cellular parameters, determined by experimental and computational work, that govern autocrine operation and the spatial range of autocrine ligands. We also present intercellular signaling pathways relevant to cell motility that may be involved in propagating localized signals from the cell surface. Finally, we review experimental findings that demonstrate how the mode of growth factor presentation can affect cell migration behavior.

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  1. Massachusetts Institute of Technology, Cambridge, MA, USA

    Elizabeth J. Joslin & Douglas A. Lauffenburger

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  1. Elizabeth J. Joslin
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  2. Douglas A. Lauffenburger
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  1. Department of Pathology, Pittsburgh VAMC, University of Pittsburgh, PA, USA

    Alan Wells

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Joslin, E.J., Lauffenburger, D.A. (2006). Autocrine Growth Factor Signaling in Motility. In: Wells, A. (eds) Cell Motility in Cancer Invasion and Metastasis. Cancer Metastasis - Biology and Treatment, vol 8. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4009-1_5

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