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Motility in Head and Neck Carcinoma

  • Chapter
Cell Motility in Cancer Invasion and Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 8))

Abstract

Head and neck squamous cell carcinoma (HNSCC) arise in areas where locoregional spread of tumors interferes with functions vital for survival. These tumors are highly aggressive with poor five-year survival rates. Understanding the mechanisms whereby HSNCC invade into the surrounding tissues may help identify novel therapeutic targets for management and prevention of tumor dissemination. Several molecules including growth factor receptors, cytokines and matrix degrading enzymes have been examined for their role in HNSCC cell invasion. In vivo animal models are being developed to test novel therapeutic strategies and investigate the mechanisms of HNSCC invasion. In this chapter an overview of the pathways implicated in HNSCC invasion, the animal models commonly used and some of the preclinical therapeutic approaches targeting HNSCC invasion are presented.

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Author information

Authors and Affiliations

  1. Department of Otolaryngology, University of Pittsburgh, University of Pittsburgh Cancer Institute and University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Sufi Mary Thomas & Jennifer Rubin Grandis

  2. Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute and University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Jennifer Rubin Grandis

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  1. Sufi Mary Thomas
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  2. Jennifer Rubin Grandis
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Editors and Affiliations

  1. Department of Pathology, Pittsburgh VAMC, University of Pittsburgh, PA, USA

    Alan Wells

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© 2006 Springer

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Thomas, S.M., Grandis, J.R. (2006). Motility in Head and Neck Carcinoma. In: Wells, A. (eds) Cell Motility in Cancer Invasion and Metastasis. Cancer Metastasis - Biology and Treatment, vol 8. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4009-1_11

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