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Microcirculation and Reperfusion Injury in Organ Transplantation

  • Conference paper
Oxygen Transport to Tissue XXVI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 566))

Abstract

There are many interesting aspects regarding hemorheology and tissue oxygenation in organ transplantation (such as liver, kidney, heart, etc.). The ischemia-reperfusion injury syndrome is a very important problem. Much damage in organs appears to be induced by reperfusion injury syndrome. In fact, not only immunological etiopathogenesis but also biochemically-mediated microcirculation alterations can modulate the organ damage induced by ischemia-reperfusion injury during organ transplantation.

During ischemia-reperfusion injury, xanthine oxidase activity, the increase in oxygen free-radicals, and the activation of neuthrophils are all very important. Platelet activating factor (PAT) and LTB4 (promoting neuthrophils adhesiveness), activated by the xanthine oxidase-derived oxidants during reperfusion, activates the final postischemia injury. Much research is necessary in order to gain a fuller knowledge of the microcirculation conditions and oxygenation during organ transplantation.

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Authors
  1. Giuseppe Cicco
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  2. P. C. Panzera
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  3. G. Catalano
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  4. V. Memeo
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Editors and Affiliations

  1. Department of Radiation Oncology, University of Rochester, Rochester, NY, 14642, USA

    Paul Okunieff , Jacqueline Williams  & Yuhchyau Chen ,  & 

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Cicco, G., Panzera, P.C., Catalano, G., Memeo, V. (2005). Microcirculation and Reperfusion Injury in Organ Transplantation. In: Okunieff, P., Williams, J., Chen, Y. (eds) Oxygen Transport to Tissue XXVI. Advances in Experimental Medicine and Biology, vol 566. Springer, Boston, MA. https://doi.org/10.1007/0-387-26206-7_48

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