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Extrasynaptic Release of Dopamine and Volume Transmission in the Retina

  • Chapter
Dendritic Neurotransmitter Release

Abstract

Retinal DA cells share with the neurons of the substantia nigra the property of releasing dopamine in absence of presynaptic active zones. As in the midbrain, the released dopamine acts on receptors at locations distant from the release sites, a modality of communication called volume or paracrine transmission. This extrasynaptic release is controlled by the electrical activity of the cell and by extrasynaptic receptors for the neurotransmitters GABA, glutamate and dopamine. Thus, in addition to the synaptic inputs onto DA cells, dopaminergic volume transmission is regulated by the integration of the passive and active properties of the DA cells surface as well as the presence of neuroactive molecules in the extracellular space.

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Authors and Affiliations

  1. Department of Neurobiology, Harvard Medical School, Boston, MA, 02115

    Michelino Puopolo, Stefano Gustincich & Elio Raviola

  2. Department of Chemistry, University of North Carolina, Chapel Hill, NC, 27599

    Spencer E. Hochstetler & R. Mark Wightman

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  1. Michelino Puopolo
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  1. Edinburgh University Medical School, Edinburgh, Scotland

    Mike Ludwig

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Puopolo, M., Hochstetler, S.E., Gustincich, S., Wightman, R.M., Raviola, E. (2005). Extrasynaptic Release of Dopamine and Volume Transmission in the Retina. In: Ludwig, M. (eds) Dendritic Neurotransmitter Release. Springer, Boston, MA. https://doi.org/10.1007/0-387-23696-1_12

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