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Dendritic Neurotransmitter Release

  • Mike Ludwig

Table of contents

  1. Front Matter
    Pages i-xv
  2. Dendritic Neurotransmitter Release, from Early Days to Today’S Challenges

  3. Morphological Studies of Dendrites and Dendritic Secretion

  4. The Lifecycle of Secretory Vesicles: Implications for Dendritic Transmitter Release

    1. David K. Apps, Michael A. Cousin, Rory R. Duncan, Ulrich K. Wiegand, Michael J. Shipston
      Pages 35-53
  5. Electrical Properties of Dendrites Relevant to Dendritic Transmitter Release

  6. Somatodendritic Dopamine Release in Midbrain

    1. Stephanie J. Cragg, Margaret E. Rice
      Pages 69-83
  7. Dopamine Release in Substantia Nigra: Release Mechanisms and Physiological Function in Motor Control

  8. Neurotransmitter Mechanisms at Dendrodendritic Synapses in the Olfactory Bulb

  9. Classical Neurotransmitters as Retrograde Messengers in Layer 2/3 of the Neocortex: Emphasis on Glutamate and Gaba

  10. The Thalamic Interneuron

    1. S. Murray Sherman
      Pages 133-144
  11. Release of Noradrenaline in the Locus Coeruleus

    1. Olga L. Pudovkina, Ben H. C. Westerink
      Pages 145-154
  12. Regulation of Somatodendritic Serotonin Release in the Midbrain Raphe Nuclei of the Rat

  13. Extrasynaptic Release of Dopamine and Volume Transmission in the Retina

    1. Michelino Puopolo, Spencer E. Hochstetler, Stefano Gustincich, R. Mark Wightman, Elio Raviola
      Pages 175-189
  14. Determinant Control of Neuronal Network Activity by Vasopressin and Oxytocin Released from Dendrites in the Hypothalamus

  15. Conditional Priming of Dendritic Neuropeptide Release

    1. Mike Ludwig, Gareth Leng
      Pages 209-221
  16. Autocrine Modulation of Excitability by Dendritic Peptide Release from Magnocellular Neurosecretory Cells

  17. Galanin, A New Candidate for Somato-Dendritic Release

    1. Marc Landry, Zhi-Qing David Xu, André Calas, Tomas Hökfelt
      Pages 239-256
  18. Dendritic Dynorphin Release in the Hippocampal Formation

    1. Carrie T. Drake, Charles Chavkin
      Pages 257-268
  19. Endocannabinoids and Gases

    1. Takako Ohno-Shosaku, Takashi Maejima, Takayuki Yoshida, Kouichi Hashimoto, Yuko Fukudome, Masanobu Kano
      Pages 269-281
    2. Catherine N. Hall, John Garthwaite
      Pages 283-300
    3. Margaret E. Rice, Marat V. Avshalumov
      Pages 301-313
    4. Hideo Kimura
      Pages 315-321
  20. Back Matter
    Pages 323-333

About this book

Introduction

The transmission of the nervous impulse is always from the dendritic branches and the cell body to the axon or functional process. Every neuron, then, possesses a receptor apparatus, the body and the dendritic prolongations, an apparatus of emission, the axon, and the apparatus of distribution, the terminal arborization of the nerve fibers. I designated the foregoing principle: the theory of dynamic polarization (Cajal 1923). Ever since the beautiful drawings from Golgi and Cajal, we have been familiar with the organisation of neurones into dendritic, somatic and axonal compartments. Cajal proposed that these cellular compartments were specialised, resulting in his concept of ^dynamic polarisation'. He considered dendrites to be passive elements that simply transferred information from inputs to the soma. Since the discovery that dendrites of many neural populations release neuroactive substances and in doing so, alter neuronal output, it is now apparent that this theory requires qualification. This book presents recent developments in the neurophysiology of dendritic release of several chemical classes of transmitters in a number of different areas of the mammalian central nervous system. Once released from a neuron, these substances can act as neurotransmitters and/or neuromodulators, to autoregulate the original neuron, its synaptic inputs, and adjacent cells or, by volume transmission, to affect distant cells. In some systems, dendritic transmitter release is part independent of secretion from axon terminal signifying a selective control of the dendritic compartment.

Keywords

brain cortex neural networks neurons neuropeptides

Editors and affiliations

  • Mike Ludwig
    • 1
  1. 1.Edinburgh University Medical SchoolEdinburghScotland

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