Abstract
Surgery, whether alone or in combination with adjuvant or neoadjuvant therapy, is a major component in the treatment of oncological disease. Patients with ablative defects following surgical resection may undergo reconstructive surgery, with the aim of returning the patient to a premorbid level, for example, a mastectomy for cancer clearance and a breast reconstruction for chest wall reconstruction. However, despite multidisciplinary involvement, aggressive surgical margins, and additional therapy, tumor recurrence may occur. Autologous tissue used for reconstruction may provide a potential therapeutic source to patients and promote long-term tumor eradication by secreting therapeutic factors. This review focuses on gene therapy as a means of ex vivo transduction of autologous tissue and describes how reconstructive tissue can offer both reconstructive and therapeutic roles in the form of therapeutic flaps.
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Davis, C.R., Than, P.A., Gurtner, G.C. (2018). Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery. In: Giatsidis, G. (eds) Gene Therapy in Reconstructive and Regenerative Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-78957-6_7
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DOI: https://doi.org/10.1007/978-3-319-78957-6_7
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