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Angiotensin 1-7 and Inflammation

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Angiotensin-(1-7)

Abstract

Ang-(1-7) binds to the G-protein-coupled MAS receptor and exerts many beneficial actions in the context of acute inflammation. Ang-(1-7) reduces production and expression of many cytokines and adhesion molecules and decreases leukocyte movement in vitro and in vivo. In animal models of inflammation, administration of Ang-(1-7) or its analogues is, in general, associated with inhibition of leukocyte influx and inflammatory tissue damage. In addition, Ang-(1-7) reduces fibrogenesis in the context of chronic inflammation. Ang-(1-7) also induces the resolution of inflammation by inducing apoptosis of neutrophils and their clearance by macrophages. Altogether, the available literature suggests that drugs that mimic the action of Ang-(1-7) on the MAS receptor may represent a novel pharmacological strategy to control and treat inflammatory diseases.

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Authors and Affiliations

  1. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Izabela Galvão, Flavia Rago & Mauro Martins Teixeira

  2. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Isabella Zaidan Moreira

Authors
  1. Izabela Galvão
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  2. Flavia Rago
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  3. Isabella Zaidan Moreira
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  4. Mauro Martins Teixeira
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Editor information

Editors and Affiliations

  1. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Robson Augusto Souza Santos

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Galvão, I., Rago, F., Moreira, I.Z., Teixeira, M.M. (2019). Angiotensin 1-7 and Inflammation. In: Santos, R. (eds) Angiotensin-(1-7). Springer, Cham. https://doi.org/10.1007/978-3-030-22696-1_13

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  • DOI: https://doi.org/10.1007/978-3-030-22696-1_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22695-4

  • Online ISBN: 978-3-030-22696-1

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