Skip to main content

Radionuclides and Their Application in Oncology Research

  • Chapter
Chemists’ Views of Imaging Centers

Abstract

The early detection of tumor, recurrence of tumor and the ability to correlate tumor response to therapy are important components of the Nuclear Medicine Service at Memorial Sloan Kettering Cancer Center. The benefit of a nuclear medicine procedure is derived from its potential to image functional processes in tissues and to monitor the response of these physiologic functions to pathologic processes and treatments. The majority of nuclear medicine methods in common practice today are qualitative in nature. The evolution of imaging equipment, the integrated computerized processing systems, and the specifically designed radiopharmaceutical compounds have the promise however, of greatly extending the assessment of physiologic processes. The potential now exists for an accurate estimate of quantitative biochemical processes both for normal and neoplastic tissues. Specific examples of radionuclides and radiopharmaceuticals applied to oncology are detailed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. Doll and R. Peto, The causes of cancer, J. Natl. Cancer Inst. 66:1191(1981).

    PubMed  CAS  Google Scholar 

  2. Trends in cancer mortality in industrial countries, edited by Davis D.I., and Hoel D., New York: NY Academy of Sciences, 1990, p.ix–xi.

    Google Scholar 

  3. E. Silverberg and J.A. Lubera, Cancer statistics, 1988. Cancer 38:5(1988).

    CAS  Google Scholar 

  4. J.F. Fraumeni, R.N. Hoover, S.S. Devesa, and L.J. Kinlen Epidemiology of cancer, in: “Cancer: Principles and Practice of Oncology,” V.T. DeVita, S. Hellman, and S.A. Rosenberg, ed., J.B. Lippincott, Philadelphia (1989).

    Google Scholar 

  5. A.M. Scott and S.M. Larson, Tumor diagnosis and therapy, in: “Radiologic Clinics of North America,” E. Coleman, ed., W.B. Saunders, Inc., New York (1993).

    Google Scholar 

  6. R.A. Weinberg, Tumor suppressor genes, Science 254:1138 (1991).

    Article  PubMed  CAS  Google Scholar 

  7. D. Wynford-Thomas, Oncogenes and anti-oncogenes: the mole-cular basis for tumor behavior, J. Path., 165:187 (1991).

    Article  PubMed  CAS  Google Scholar 

  8. H. Macapinlac, A. Scott, F. Daghighian, S. Yeh, J. Ginos, J. Tjuvajev, J. Zhang, R. Finn, S. Larson, and R. Blasberg, I-131-Iododeoxyuridine (IUdR) imaging of brain tumor proliferative activity, Clin. Nucl. Med. 18:263(1993).

    Article  Google Scholar 

  9. J. Ginos, R. Finn, P. Kothari, R. Blasberg, and S. Larson, An investigation into the preparation and chemical stability of radiohalogenated deoxyuridines (UdR) for SPECT and PET imaging. Third International Symposium on Radiohalogens, Banff Centre for Conferences, Banff, Alberta, Canada 9/20–23, 1992 (Abstract).

    Google Scholar 

  10. H. Macapinlac, J. Finlay, C. Caluser, S. Yeh, A. Scott, R. DeLaPaz, K. Lindsley, R. Finn, S. Larson, and H. Abdel Dayem, Comparison of Tl-201 SPECT and F- 18 FDG PET imaging with MRI (Gd-DTPA) in the evaluation of recurrent supratentorial and infratentorial tumors, J. Nucl. Med. 33:867(1992).

    Google Scholar 

  11. H. Macapinlac, A. Scott, C. Caluser, S. Yeh, J. Finlay, R. DeLaPaz, K. Lindsley, S. Al-Mohannadi, H. Abdel-Dayem, and S. Larson, Utility of Tl-201 SPECT and F-18 FDG PET as an adjunct to CT and MR Imaging in the evaluation of metastatic brain tumors, Radiology 185:P233(1992).

    Google Scholar 

  12. C.A. Pellizari, G.T.Y. Chen, et al., Accurate three dimensional registration of CT, PET and/or MRI inages of the brain, J. Comput. Assist. Tomogr. 14:20(1989).

    Article  Google Scholar 

  13. H. Macapinlac, J. Zhang, H. Kalaigian, S. Yeh, A. Scott, C. Caluser, R. DeLaPaz, J. Finlay, R. Blasberg, G. DiResta, R. Finn, K. Lindsley, M. Bernstein, and S. Larson, Registration of Tl-201 SPECT and PET images in patients with primary brain tumors, Radiology 185:P234(1992).

    Google Scholar 

  14. I. Pastan, M.M. Gottesmann, Multiple-drug resistance in human cancer, N. Eng. J. Med. 316:1388(1987).

    Article  CAS  Google Scholar 

  15. V. Ling, P-glycoprotein and resistance to anti-cancer drugs, in: “Accomplishments in Cancer Research 1991,” J.G. Fortner and J.E. Rhoads, eds., J.B. Lippincott Co., Philadelphia(1991).

    Google Scholar 

  16. J.M. Fort, and W.N. Hait. Pharmacology of drugs that alter multidrug resistance in cancer, Pharmacol. Rev. 42:155(1990).

    Google Scholar 

  17. T. Tsuruo, Mechanisms of multidrug resistance and im-plications for therapy, Jpn. J. Cancer Res. 79:285(1988).

    CAS  Google Scholar 

  18. T. Tsuruo, H. Iida, S. Tsukagoshi, et al., Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil, Cancer Res. 41:1967 (1981).

    PubMed  CAS  Google Scholar 

  19. L.M. Slater, P. Sweet, J. Stupecky, et al., Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro, J. Clin. Invest. 77:1405(1986).

    Article  PubMed  CAS  Google Scholar 

  20. M. Naito, T. Oh-Hara, A. Yamazaki, et al., Reversal of multidrug resistance by an immunosuppressive agent FK-506, Cancer Chemother. Pharmacol. 29:195(1992).

    CAS  Google Scholar 

  21. D.E. Merkel, S.A.W. Fuqua, A.K. Tandon, S.M. Hill, A.U. Buzdar, and W.L. McGuire, Electrophoretic analysis of 248 clinical breast cancer specimens for P-glyco-protein overexpression or gene amplification, J. Clin. Oncol. 7:1129(1989).

    PubMed  CAS  Google Scholar 

  22. P. Verelle, F. Meissonmier, Y. Fonck, et al., Clinical relevance of immunohistochemical detection of multidrug-resistance in breast carcinoma, J. Natl. Cancer Inst. 83:111(1991).

    Article  Google Scholar 

  23. B.M. Mehta, E. Rosa, J.D. Fissekis, J.R. Bading, J.L. Biedler, and S.M. Larson, In-vivo identification of tumor multidrug resistance with 3H-colchicine, J. Nucl. Med. 33:1373(1992).

    PubMed  CAS  Google Scholar 

  24. H. Hamada and T. Tsuruo, Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies, Proc. Natl. Acad. Sci. U.S.A. 83:7785(1986).

    Article  PubMed  CAS  Google Scholar 

  25. H.J. Broxterman, C.M. Kuiper, G.J. Schuurhuis, T. Tsuruo, H.M.N. Pinedo, and J. Kankelma, Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein, Biochem. Pharmacol. 37:2389(1989).

    Google Scholar 

  26. T. Tsuruo, H. Hamada, S. Sato, et al., Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies. Jpn. J. Cancer Res. 80:627(1989).

    Article  PubMed  CAS  Google Scholar 

  27. J.W. Pearson, W.E. Fogler, K. Volker, et al., Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody, J. Natl. Cancer Inst. 83:1386(1991).

    Article  PubMed  CAS  Google Scholar 

  28. M. Naito, H. Tsuge, C. Kuroko, et al., Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. J. Natl. Cancer Inst. 85:311(1993).

    Article  PubMed  CAS  Google Scholar 

  29. P.J. Fraker and J.C. Speck, Protein and cell membrane iodination with a sparingly soluble chloramide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycouril, Biochem. Biophys. Res. Commun. 80:849(1978).

    Article  CAS  Google Scholar 

  30. J.L. Biedler, D. Casals, T-D. Chang, M.B. Meyers, B.A. Spengler, and R.A. Ross, Multidrug-resistant human neuroblastoma cells are more diffferentiated than controls and retinoic acid further induces lineage-specific differentiation, Adv. Neuroblast. Res. 3:181(1991).

    Google Scholar 

  31. J.C. Sisson, M.S. Fager, T.W. Valk, M.D. Gross, D.P. Swanson, D.M. Wieland, M.C. Tbes, and W.H. Beierwaltes, Scintigraphic localization of pheo-chromocytoma, N. Engl. J. Med. 305:12(1981).

    Article  PubMed  CAS  Google Scholar 

  32. S.D.J. Yeh, L. Helson, and R.S. Benua, Correlation between iodine-131 MIBG imaging and biological markers in advanced neuroblastoma, Clin. Nucl. Med. 13:46(1988).

    CAS  Google Scholar 

  33. S.D.J. Yeh, S.M. Larson, L. Burch, R.H. Kushner, M. Laquaglia, R.D. Finn, N.K-V. Cheung, Radioimmuno-detection of neuroblastoma with iodine-131–3F8: correlation with biology, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities, J. Nucl. Med. 32:769(1991).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Finn, R.D. et al. (1995). Radionuclides and Their Application in Oncology Research. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9670-4_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9672-8

  • Online ISBN: 978-1-4757-9670-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics