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Chemoprevention of Experimental Tumorigenesis by Dehydroepiandrosterone and Structural Analogs

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Chemical Carcinogenesis

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Abstract

The human adrenal cortex secretes three classes of steroid hormone: glucocorticoid, mineralcorticoid and the so-called adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA-sulfate. The term adrenal androgen is not strictly accurate since DHEA per se is not androgenic and only through metabolism to steroids such as testosterone does it exert such action. DHEA-sulfate is also a principal source of estrogen, through placental metabolism, in the pregnant female1,2. However, in the normal male and female the proportion of sex steroids derived from adrenal DHEA is very small compared to the gonadal contribution, and the significance of the adrenal secretion of DHEA and DHEA-sulfate remains unclear3.

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Author information

Authors and Affiliations

  1. Fels Research Institute and Department of Microbiology, Temple University Medical School, Philadelphia, PA, 19140, USA

    Arthur G. Schwartz, Laura L. Pashko, Laura A. Hastings & Jeannette H. Whitcomb

  2. Steroid Laboratory, Crozer-Chester Hospital, Chester, PA, 19013, USA

    Marvin L. Lewbart

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  1. Arthur G. Schwartz
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  2. Laura L. Pashko
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  4. Jeannette H. Whitcomb
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  5. Marvin L. Lewbart
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Editors and Affiliations

  1. University of Sassari, Sassari, Italy

    Francesco Feo  & Renato Garcea  & 

  2. University of Cagliari, Cagliari, Italy

    Paolo Pani  & Amedeo Columbano  & 

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Schwartz, A.G., Pashko, L.L., Hastings, L.A., Whitcomb, J.H., Lewbart, M.L. (1988). Chemoprevention of Experimental Tumorigenesis by Dehydroepiandrosterone and Structural Analogs. In: Feo, F., Pani, P., Columbano, A., Garcea, R. (eds) Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9640-7_41

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  • DOI: https://doi.org/10.1007/978-1-4757-9640-7_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9642-1

  • Online ISBN: 978-1-4757-9640-7

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