Abstract
Cyclosporine (CsA) a potent immunosuppressive drug which has afforded benefit in transplantation and in the treatment of several immune-mediated diseases (1–3). However, a number of side effects have been observed, with nephrotoxicity being the most common and important (4–6). The impairment of glomerular filtration rate (GFR) and thus, acute renal failure (ARF) observed with CsA appears to be related with renal haemodynamic alterations (7,8) . No significant glomerular lesions have been found (4).
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Barros, E.J.G., Boim, M.A., Moura, L.A.R., Ramos, O.L., Schor, N. (1989). Effects of Acute and Chronic Cyclosporine Administration on Glomerular Haemodynamics in Rats. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_47
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DOI: https://doi.org/10.1007/978-1-4757-2040-2_47
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