Abstract
Recently, the selective necrosis of renal convoluted (CPT) and straight proximal tubules (SPT) following administration of K2Cr2O7 and HgCl2, respectively, has been reproduced in renal cortical slices (Ruegg et al, 1987a). This demonstrates that the toxicity of these two metals results from the innate sensitivity of these segments of the nephron to the specific metal and is not a result of altered blood flow or feed-back mechanisms . The question remains as to why these nephron segments are specifically intoxicated. Is it the result of a specific uptake and localization of the metals in the intoxicated cells?
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berlin M and Ullberg S. Accumulation and retention of mercury in the mouse. I . An autoradiographic study after a single intravenous injection of mercuric chloride. Arch Environ Health 6:589–601, 1963.
Berndt WO. Renal chromium accumulation and its relationship to chromiuminduced nephrotoxicity . J Toxicol Environ Health 1: 449–459, 1976 .
Berndt WO, Baggett JM, Blacker A and House M. Renal glutathione and mercury uptake by kidney. Fund Appl Toxicol 5:832–839, 1985.
Danscher G and Moller-Madsen B. Silver amplification of mercury sulfide and selenide: A histochemical method for light and electron microscopic localization of mercury in tissue. J Histochem Cytochem 33:219–228, 1985 .
Hassall CD, Gandolfi AJ, Brendel K. Effect of halogenated vinyl cysteine conjugates on renal tubular active transport . Toxicology 26:285–294, 1983 .
Mescon H and Flesch P . Modification of Bennett’ s method for the histochemical demonstration of free sulfhydryl groups in skin. J Invest Dermatology 17:261–266, 1952 .
Moreton RB. Electron-probe x-ray microanalysis: Techniques and recent applications in biology. Biol Rev 56: 409–461, 1981 .
Ruegg CE, Gandolfi AJ, Brendel K, Nagle FB. Differential Patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions . Toxicol Appl Pharmacol, in press, 1987a.
Ruegg CE, Gandolfi AJ, Brendel K, Nagle RB, and Krumdieck CL. Preparation of positional renal slices for study of site-specific toxicity. J Pharm Methods 17: 111–123, 1987b.
Ruegg CE. Mechanisms underlying regioselective acute tubular necrosis of renal proximal tubular segments. Doctoral Thesis, University of Arizona, 1987c.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ruegg, C.E., Gandolfi, A.J., Brendel, A.K. (1989). Regioselective Acute Tubular Necrosis in Renal Cortical Slices Following HgCl2 and K2Cr2O7: Localization and Transport Studies. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_17
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2040-2_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2042-6
Online ISBN: 978-1-4757-2040-2
eBook Packages: Springer Book Archive