Abstract
During the past ten years, since its introduction by Rundles and his colleagues, allopurinol has gained widespread favor in the treatment of gout and other hyperuricemic states (1). Although it is conventional to prescribe allopurinol in multiple divided doses each day, the drug is metabolized in man in such a way as to suggest that a single daily dose may prove equally effective.
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References
Rundles, R.W., Wyngaarden, J.B., Hitchings, G.H., Elion, G.B., and Silberraan, H.R. Trans. Assoc. Amer, Physicians, 76: 126–140 1963.
Elion, G.B., Kovensky, A., Hitchings, G.H., Metz, E., and Rundles, R.W. Biochem Pharmacol. 15: 863–880, 1966.
Elion, G.B., Yü, T.F., Gutraan, A.B., and Hitchings, G.H. Amer. J. Med. 45: 69–77, 1968.
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© 1974 Springer Science+Business Media New York
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Rodnan, G.P., Robin, J.A., Tolchin, S.F. (1974). Efficacy of Single Daily Dose Allopurinol in Gouty Hyperuricemia. In: Sperling, O., De Vries, A., Wyngaarden, J.B. (eds) Purine Metabolism in Man. Advances in Experimental Medicine and Biology, vol 41. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1433-3_26
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DOI: https://doi.org/10.1007/978-1-4757-1433-3_26
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