Abstract
One of the identified products of enzyme action on prostaglandin endoperoxides is the highly unstable thromboxane A2 (TXA2) (Samuelsson et al., 1976). This substance, though short-lived biologically, has effects far exceeding that of either prostaglandin endoperoxide (PGH2 or PGG2) or PGF2α. As a product of cell membrane-derived arachidonic acid via the cyclooxygenase pathway, TXA2 is produced in tissues and cells of vastly different origin (Table 1). As a result, TXA2 has a number of characteristic actions (e.g., induction of platelet aggregation, contraction of vascular and respiratory smooth muscle and is pro-ulcerogenic/cytodestructive in the GI tract). Additionally, TXA2 action has been shown to be mediated through a discrete class of thromboxane receptors (Jones et al., 1982).
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© 1985 Plenum Press, New York
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Malo, P.E., Wasserman, M.A., Osborn, R.R. (1985). Evidence for a Thromboxane Antagonist in Selected In Vitro and In Vivo Systems. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_20
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