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Interaction of Embryonic Stem Cells with the Immune System

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The Immunological Barriers to Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Embryonic stem (ES) cells interact with the immune system in unique ways. Immune interactions of ES cells and tumor formation appear to be reciprocal functions—the less immunity ES cells provoke, the greater the risk of tumor formation. Knowledge of the interaction of ES cells and their derivatives with the immune system and their relationship to tumor formation is critical to their potential therapeutic applications to regenerative medicine.

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Acknowledgments

Supplemented by grants from the NIH: HL52297.

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Authors and Affiliations

  1. Department of Otorhinolaryngology—Head and Neck Surgery, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA

    Cody A. Koch

  2. Departments of Surgery and of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA

    Jeffrey L. Platt

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  1. Cody A. Koch
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  2. Jeffrey L. Platt
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Correspondence to Cody A. Koch .

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    Paul J. Fairchild

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Koch, C.A., Platt, J.L. (2013). Interaction of Embryonic Stem Cells with the Immune System. In: Fairchild, P. (eds) The Immunological Barriers to Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5480-9_3

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