Abstract
The evidence that most animal carcinogens are also mutagens,(20,24) strongly suggesting that DNA is the ultimate target of carcinogenic activation, has been an important support of the somatic mutation theory of the etiology of cancer. The recent demonstration that a single point mutation, a GC to TA transversion, leads to the activation of a human oncogene(30,36) is in agreement with this suggestion.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
B. N. Ames, W. E. Durston, E. Yamasaki, and F. D. Lee, Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection,Proc. Natl. Acad. Sci. USA 70, 2281–2285 (1973).
B. N. Ames, F. D. Lee, and W. E. Durston, An improved bacterial test system for the detection and classification of mutagens and carcinogens,Proc. Natl. Acad. Sci. USA 70, 782–786 (1973).
B. N. Ames, J. McCann, and E. Yamasaki, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test,Mutat. Res. 31, 347–364 (1975).
P. Arni, TV Mantel, E. Deparade, and D. Müller, Intrasanguine host-mediated assay withSalmonella typhimurium, Mutat. Res. 45, 291–307 (1977).
B. E. Butterworth, Recommendations for practical strategies for short-term testing for mutagens/carcinogens, in:Strategies for Short-Term Testing for Mutagens/Carcinogens (B. E. Butterworth, ed.), pp. 89–102, CRC Press, West Palm Beach (1979).
E. Englesberg, Enzymatic characterization of 17L-arabinose negative mutants ofEscherichia coli, J. Bacteriol.81, 996–1006 (1961).
E. Englesberg, Regulation in theL-arabinose system, in:Metabolic Pathways (H. J. Vogel, ed.), Vol. 5, pp. 257–296, Academic Press, New York (1971).
E. Englesberg, R. L. Anderson, R. Weinberg, N. Lee, P. Hoffee, G. Huttenhauer, and H. Boyer, L-Arabinose-sensitive, L-ribulose 5-phosphate 4-epimerase-deficient mutants ofEscherichia coli, J. Bacteriol.84, 137–146 (1962).
E. Englesberg and G. Wilcox, Regulation: Positive control,Annu. Rev. Genet.8, 219– 242 (1974).
R. Fahring, Development of host-mediated mutagenicity tests, I. Differential response of yeast cells injected into testes of rats and peritoneum of mice and rats to mutagens,Mutat. Res. 26, 29–36 (1974).
R. Fahring, Development of host–mediated mutagenicity tests-yeast systems II. Recovery of yeast cells out of testes, liver, lungs, and peritoneum of rats,Mutat. Res. 31, 381–394 (1975).
G. Ficsor, R. D. Beyer, F. C. Janca, and D. M. Zimmer, An organ-specific host-mediated microbial assay for detecting chemical mutagensin vivo: Demonstration of mutagenic action in rat testes following streptozotocin treatment,Mutat. Res. 13, 283–287 (1971).
M. G. Gabridge and M. S. Legator, A host-mediated microbial assay for the detection of mutagenic compounds,Proc. Soc. Exp. Biol. Med. 130, 831–834 (1969).
N. Guerola, J. L. Ingraham, and E. Cerda-Olmedo, Induction of closely–linked multiple mutations by nitrosoguanidine,Nature 230, 122–125 (1971).
M. H. L. Green and W. J. Muriel, Mutagen testing using Trp+ reversion inEscherichia coli, Mutat. Res. 38, 3–32 (1976).
M. Hollstein and J. McCann, Short-term tests for carcinogens and mutagens,Mutat. Res. 65, 133–226 (1979).
D. E. Levin, E. Yamasaki, and B. N. Ames, Anew Salmonella tester strain TA97, for the detection of frameshift mutagens. A run of cytosines as a mutational hot-spot,Mutat. Res. 94, 315–330 (1982).
H. V. Mailing and C. N. Frantz, Metabolic activation of dimethylnitrosamine and diethylnitrosamine to mutagens,Mutat. Res. 25, 179–186 (1974).
I. E. Mattern, Bases of evaluation of an Ames test, in:Progress in Environmental Mutagenesis and Carcinogenesis (A. Kappas, ed.) Vol. 2, pp. 187–189, Elsevier Biomedical Press, Amsterdam (1981).
J McCann E Choi E Yamasaki BN Ames Detection of carcinogens as mutagens in theSalmonella/microsome test: Assay of 300 chemicalsProc. Natl. Acad. Sei. USA 72, 5135–5139 (1975).
J. McCann, N. E. Spingarn, J. Kobori, and B. N. Ames, Detection of carcinogens as mutagens. Bacterial tester strains with R factor plasmids,Proc. Natl. Acad. Sei. USA 72, 979–983 (1975).
G. Mohn and J. Ellenberger, Mammalian blood-mediated mutagenicity test using a multipurpose strain ofEscherichia coli K–12,Mutat. Res. 19, 257–260 (1973).
G. Mohn, J. Ellenberger, D. McGregor, and H. J. Merker, Mutations in plants, microorganisms and in host-mediated assay,Mutat. Res. 29, 221–233 (1975).
M. Nagao, T. Sugimura, and T. Matsushima, Environmental mutagens and carcinogens,Annu. Rev. Genet. 12, 117–159 (1978).
C. Pueyo, Forward mutations to arabinose resistance inSalmonella typhimurium strains. A sensitive assay for mutagenicity testing,Mutat. Res. 54, 311–321 (1978).
C. Pueyo, Natulan induces forward mutations to L-arabinose-resistance inSalmonella typhimurium, Mutat Res. 67, 189–192 (1979).
C. Pueyo, D. Frezza, and B. Smith, Evaluation of three metabolic activation systems by a forward mutation assay inSalmonella, Mutat. Res. 64, 183–194 (1979).
C. Pueyo and J. Lopez-Barea, The L-arabinose-resistance test ofSalmonella typhimurium strain SV3 selects forward mutations at severalara genes,Mutat. Res. 64, 249–258 (1979).
I. F. H. Purchase, ICPEMC Working Paper 2/6. An appraisal of predictive tests for carcinogenicity,Mutat. Res. 99, 53–71 (1982).
E. P. Reddy, R. K. Reynolds, E. Santos, and M. Barbacid, A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene,Nature 300, 149–152 (1982).
M. Ruiz-Rubio and C. Pueyo, Double mutants with both His reversion and Ara forward mutation systems ofSalmonella, Mutat. Res. 105, 383–386 (1982).
R. Ruiz-Vazquez, C. Pueyo, and E. Cerda-Olmedo, A mutagen assay detecting forward mutations in an arabinose–sensitive strain ofSalmonella typhimurium, Mutat. Res. 54, 121–129 (1978).
L. E. Sacks and J. T. MacGregor, TheB. subtilis multigene sporulation test for mutagens: Detection of mutagens inactive in the Salmonellahis reversion test,Mutat. Res. 95, 191–202 (1982).
D. E. Sheppard and D. A. Walker, Polarity in genearaB of theL-arabinose operon inEscherichia coli B/r,J. Bacteriol. 100, 715–723 (1969).
T. R. Skopek, H. L. Liber, J. J. Krolewski, and W. G. Thilly, Quantitative foward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker, Proc. Natl. Acad. Sci. USA 75, 410–414 (1978).
C. J. Tabin, S. M. Bradley, C. I. Bargmann, R. A. Weinberg, A. G. Papageorge, E. M. Scolnick, R. Dhar, D. R. Lowy, and E. H. Chang, Mechanism of activation of a human oncogene,Nature 300, 143–149 (1982).
L. A. Wheeler, J. H. Carter, F. B. Soderberg, and P. Goldman, Association ofSalmonella mutants with germfree rats: Site specific model to detect carcinogens as mutagens,Proc. Natl. Acad. Sci. USA 72, 4607–4611 (1975).
W. Z. Whong, J. Stewart, and T. M. Ong, Use of the improved arabinose-resistant assay system ofSalmonella typhimurium for mutagenesis testing,Environ. Mutagen. 3, 95–99 (1981).
R. G. Wilkinson, R. Gemski, and B. A. D. Stocker, Non-smooth mutants ofSalmonella typhimurium. Differentiation by phage sensitivity and genetic mapping,J.Gen. Microbiol. 70, 527–554 (1972).
M. Ruiz–Rubio, C. Hera, and C. Pueyo. Comparison of a forward and a reverse mutation assay inSalmonello typhimurium measuringL-arabinose resistance and histidine prototrophy,EMBO Journal, in press (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pueyo, C., Ruiz-Rubio, M. (1984). The L-Arabinose Resistance Test with Salmonella typhimurium . In: de Serres, F.J. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2771-4_3
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2771-4_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9711-6
Online ISBN: 978-1-4613-2771-4
eBook Packages: Springer Book Archive