Overview
- Editors:
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Paul D. Robbins
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University of Pittsburgh, USA
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Table of contents (30 protocols)
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- Ning-Sun Yang, Dennis E. McCabe, William F. Swain
Pages 281-296
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- Gary J. Nabel, Zhi-yong Yang, Elizabeth G. Nabel
Pages 297-305
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- Kyonghee Son, Frank Sorgi, Xiang Gao, Leaf Huang
Pages 329-337
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- Zhihai Qin, Thomas Blankenstein
Pages 339-348
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- Elaine M. Elder, Michael T. Lotze, Theresa L. Whiteside
Pages 349-356
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- Richard Kang, Paul D. Robbins, Christopher H. Evans
Pages 357-368
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- Toshiya Shitara, Kevin J. Scanlon
Pages 391-401
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- Wei-Wei Zhang, Jack A. Roth
Pages 403-418
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Back Matter
Pages 419-432
About this book
In the last few years, significant advances have been made in the area of gene therapy for both genetic and acquired diseases. Improvement in gene transfer methods has allowed for development of gene therapy protocols for the treatment of diverse types of diseases, including metabolic, cardiovas- lar, and autoimmune diseases, as well as cancer. For example, clinical trials for gene therapy of cancer, cystic fibrosis, ADA deficiency, and arthritis, among others, have been initiated in recent years. It is likely that, in the near future, gene therapy will become a common form of treatment for many different types of diseases. Gene therapy takes advantage of recent advances in many areas of molecular and cell biology, including the identification of new the- peutic genes, improvement in both viral and nonviral gene delivery systems, better understanding of gene regulation, and improvement in cell isolation and transplantation. Because of the different and complex techniques involved in achieving successful gene-mediated therapies, it is difficult for scientists to perform all methods required for gene delivery and subsequent in vivo gene expression. This Gene Therapy Protocols volume in the Methods in Molecular Me- cine series provides scientists with detailed methods for working with gene transfer systems, and methods for gene transfer to specific tissue types either in vivo or ex vivo.
Reviews
Such a compilation is of great interest fro researchers who get interested in the protocols utilized in gene transfer and in thier applications. Furthermore, for researchers already involved in gene therapy, this book is a very good reference with a "note section" containing many details and comments, useful to improve current protocols.-ACTA Neurologica Belgica
Editors and Affiliations
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University of Pittsburgh, USA
Paul D. Robbins