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Rabbit Biotechnology

  • Louis-Marie Houdebine
  • Jianglin Fan

Table of contents

  1. Front Matter
    Pages i-viii
  2. Louis-Marie Houdebine, Jianglin Fan
    Pages 1-2
  3. Shuji Kitajima
    Pages 3-12
  4. Kazutoshi Nishijima
    Pages 13-22
  5. Tomonari Koike, Jifeng Zhang, Jianglin Fan
    Pages 23-26
  6. Masashi Morimoto
    Pages 27-35
  7. Shuji Kitajima, Enqi Liu, Jianglin Fan
    Pages 37-47
  8. Louis-Marie Houdebine, Geneviève Jolivet, Pierre-Jean Ripoll
    Pages 65-75
  9. Andras Dinnyes, Zsuzsanna Polgar, Qinggang Meng
    Pages 105-128
  10. Jessica Alföldi, Federica Di Palma, Kerstin Lindblad-Toh
    Pages 129-129
  11. Back Matter
    Pages 131-132

About this book

Introduction

Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.

Keywords

biological functions biotechnology cell lines cloning genes genome metabolism

Editors and affiliations

  • Louis-Marie Houdebine
    • 1
  • Jianglin Fan
    • 2
  1. 1.Institute of Research in AgronomyJouy en JosasFrance
  2. 2.Department of Molecular Pathology, Interdisciplinary Graduate, School of Medicine and EngineeringUniversity of YamanashiYamanashiJapan

Bibliographic information

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