Overview
Provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field
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Table of contents (32 papers)
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Overview of Paroxysmal Nocturnal Hemoglobinuria
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Pathogenesis and Animal Models of PNH
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Clinical Pathology and Natural History of PNH
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Mechanism of Clonal Expansion in PNH
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PNH Clones Under Bone Marrow Failure
Keywords
About this book
Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.
Editors and Affiliations
Bibliographic Information
Book Title: Paroxysmal Nocturnal Hemoglobinuria and Related Disorders
Book Subtitle: Molecular Aspects of Pathogenesis
Editors: Mitsuhiro Omine, Taroh Kinoshita
DOI: https://doi.org/10.1007/978-4-431-67867-0
Publisher: Springer Tokyo
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eBook Packages: Springer Book Archive
Copyright Information: Springer Japan 2003
Hardcover ISBN: 978-4-431-70329-7Published: 09 December 2002
Softcover ISBN: 978-4-431-68004-8Published: 12 October 2012
eBook ISBN: 978-4-431-67867-0Published: 06 December 2012
Edition Number: 1
Number of Pages: XVIII, 285
Topics: Hematology
Industry Sectors: Biotechnology, Health & Hospitals, Pharma