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  • © 2018

Immunopharmacology and Inflammation

  • Includes atherosclerosis, ischemic-reperfusion injury, sepsis/multiply organ failure and COPD

  • Discusses current trends in inflammatory mediator and anti-inflammatory drug research

  • Presents an array of therapeutic approaches towards both inflammatory and autoimmune diseases

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-77658-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 219.99
Price excludes VAT (USA)
Hardcover Book USD 219.99
Price excludes VAT (USA)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
  2. The Molecular Mechanisms of Inflammation

    1. Front Matter

      Pages 1-1
    2. Mediators of Inflammation

      • Izabela Galvão, Michelle A. Sugimoto, Juliana P. Vago, Marina G. Machado, Lirlândia P. Sousa
      Pages 3-32
    3. Innate Immunity and Inflammation: The Molecular Mechanisms Governing the Cross-Talk Between Innate Immune and Endothelial Cells

      • Daiane Boff, Caio Tavares Fagundes, Remo Castro Russo, Flavio Almeida Amaral
      Pages 33-56
    4. Adaptive Immunity of Airway Inflammation in Asthma

      • Cameron H. Flayer, Sarah S. Killingbeck, Erik Larson, Zoulfia Allakhverdi, Angela Haczku
      Pages 57-84
    5. Role of Histamine in Inflammatory Diseases

      • Anette T. Hansen Selnø, Vadim V. Sumbayev, Ulrike Raap, Bernhard F. Gibbs
      Pages 85-106
  3. Resolution of Inflammation

    1. Front Matter

      Pages 131-131
    2. Pro-resolving Mediators

      • William Antonio Gonçalves, Alesandra Côrte Reis Melão, Mauro Martins Teixeira, Barbara Maximino Rezende, Vanessa Pinho
      Pages 133-175
  4. Immunopharmacology

    1. Front Matter

      Pages 177-177
    2. Innate Immunity in Inflammation

      • Andrea Cignarella, Chiara Bolego
      Pages 179-190
    3. Regulatory Mechanisms in Neutrophil Degranulation

      • Lindsey C. Felix, Sarah Almas, Paige Lacy
      Pages 191-210
    4. Immune Mechanisms in Atherosclerosis and Potential for Immunomodulatory Therapies

      • Gianluca Grassia, Neil MacRitchie, Pasquale Maffia
      Pages 211-224
    5. Regulation of Immunity and Disease by the IL-1 Receptor Family Members IL-1R2 and IL-1R8

      • Martina Molgora, Domenico Supino, Cecilia Garlanda
      Pages 225-246
  5. Classical Drugs to Treat Inflammatory and Autoimmune Diseases

    1. Front Matter

      Pages 247-247
    2. Glucocorticoids: Molecular Mechanisms of Action

      • Diana Cruz-Topete, John A. Cidlowski
      Pages 249-266
    3. Glucocorticoids: Immunity and Inflammation

      • Simona Ronchetti, Carlo Riccardi
      Pages 267-281
    4. Strategies and Compounds to Circumvent Glucocorticoid-Induced Side Effects

      • Astrid Luypaert, Wim Vanden Berghe, Jan Tavernier, Claude Libert, Karolien De Bosscher
      Pages 283-305
  6. Innovative Drugs to Treat Inflammatory and Autoimmune Diseases

    1. Front Matter

      Pages 307-307
    2. Innovative Drugs for Allergies

      • Ekaterini Tiligada, Kyriaki Gerasimidou, Francesca Levi-Schaffer
      Pages 309-321

About this book

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system, and pharmacology. Immunopharmacology and Inflammation meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields. 

Keywords

  • chronic disease
  • pathogens
  • biological mediator
  • metabolic disease
  • autoimmune disease

Editors and Affiliations

  • Department of Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy

    Carlo Riccardi

  • Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Francesca Levi-Schaffer

  • Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

About the editors

Carlo Riccardi is full professor of Pharmacology at the Perugia University Medical School, Italy, and currently the Director of the Department of Medicine. Prof. Riccardi completed both his Pharmacy and Medical degrees at the University of Perugia, and a period as a Research Associate, at the Department of Pathology, State University of New York at Buffalo. He was also Guest Visitor in the Laboratory of Immunodiagnosis, N.C.I., N.I.H., in Bethesda, Maryland. His field of research is the immunopharmacology, with a particular focus on the molecular mechanisms of action of glucocorticoids in inflammation and the mechanisms regulating the lymphocyte activation, growth and differentiation. These studies have been the subject of more than 270 publications in international journals. He participated to numerous congresses and meetings worldwide as invited speaker and/or chairman for his competences in Pharmacology, Inflammation and Immunology, Glucocorticoids, Apoptosis, Cell Growth Regulation, GILZ and GITR. He is member of the Editorial Board and referee of many international scientific Journals. He is also member of many scientific societies, such as International Association of Inflammation Societies, IUPHAR, and Italian Society of Pharmacology, of which he has been President. Throughout his career, he has obtained several grants to develop and work in the research field of pharmacology.

Francesca Levi-Schaffer is a Professor at The Hebrew University of Jerusalem Institute for Drug Research, School of Pharmacy, Faculty of Medicine. She holds the Isaac and Myrna Kaye Chair in Immunopharmacology. Prof. Levi-Schaffer was born in Italy and completed her PharmD degree at the University of Milano, her PhD degree in Immunology at the Weizmann Institute, Israel, and her post-doctorate at Harvard Medical School. Prof. Levi-Schaffer has published 160 articles in peer-reviewed journals, 83 reviews and editorials and 25 book chapters. She has two patents and one provisional patent. She is Chairperson of the National Committee of IUPHAR representing the Israel Academy of Sciences and Humanities, was instrumental in the establishment of an Immunopharmacology Section in the IUPHAR and currently serves as its first Chairperson. She is a member of the Israeli Ministry of Health Committee for Human Experimentation of New Drugs; a Councilor and member of the IUPHAR Executive Committee; member of the Board, treasurer (2016-18), and Secretary General (2018-20) of World Allergy Organization; and Council member of Collegium Internationale Allergologicum.

Prof. Levi-Schaffer's expertise is in immunopharmacology of allergy focusing on mast cells and eosinophils, their activating and inhibitory receptors, their cross-talk for a better prophylaxis/treatment of allergic diseases.

Ekaterini Tiligada graduated from University College Cardiff, UK, received her PhD from University of Wales College of Medicine, UK. She subsequently joined the Medical School, National and Kapodistrian University of Athens, Greece, where she is currently Professor of Experimental Pharmacology and coordinates the Immunopharmacology group.

During the last 25 years she has focused her research on inflammatory and immune-related processes, with particular interest in the functional role of histamine and histamine receptors in human pathophysiology. Her other areas of interest include the cellular stress response and drug hypersensitivity reactions. She has published over 100 peer reviewed papers and 10 book chapters. She has an extensive experience in teaching undergraduate and postgraduate medical and dental students and in training and supervising young researchers. She is currently Council Officer of the European Histamine Research Society, Treasurer of the IUPHAR Immunopharmacology Section and Observer in the Rheumatology-Immunology Working Party of the European Medicines Agency.

Bibliographic Information

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-77658-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 219.99
Price excludes VAT (USA)
Hardcover Book USD 219.99
Price excludes VAT (USA)