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Regulation of Immunity and Disease by the IL-1 Receptor Family Members IL-1R2 and IL-1R8

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Abstract

Interleukin-1 and other IL-1 family members are key players in immunity and inflammation.

The activation of the IL-1 system is tightly regulated, through ligands with antagonistic or anti-inflammatory activity, or decoy and negative regulatory receptors. IL-1R2 and IL-1R8 (also known as SIGIRR) are members of the ILR family acting as negative regulators of the IL-1 system. IL-1R2 binds IL-1 and the accessory protein IL-1RAcP without activating signaling, thus modulating IL-1 availability for the signaling receptor. IL-1R8 dampens IL-1 receptor- and Toll Like Receptor-mediated cell activation and is a component of the receptor complex recognizing the anti-inflammatory cytokine IL-37.

The deregulated activation of the IL-1 system is the potential cause of detrimental local or systemic inflammatory reactions. Here, we summarize our current understanding of the function of IL-1R2 and IL-1R8, focusing on their role in pathological conditions, ranging from infectious and sterile inflammation, to cancer-related inflammation.

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Authors and Affiliations

  1. Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, Italy

    Martina Molgora, Domenico Supino & Cecilia Garlanda

  2. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy

    Cecilia Garlanda

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  1. Martina Molgora
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  2. Domenico Supino
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  3. Cecilia Garlanda
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Correspondence to Cecilia Garlanda .

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Editors and Affiliations

  1. Department of Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy

    Carlo Riccardi

  2. Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Francesca Levi-Schaffer

  3. Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

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Molgora, M., Supino, D., Garlanda, C. (2018). Regulation of Immunity and Disease by the IL-1 Receptor Family Members IL-1R2 and IL-1R8. In: Riccardi, C., Levi-Schaffer, F., Tiligada, E. (eds) Immunopharmacology and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-77658-3_10

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