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  • © 2018

Drug Resistance in Leishmania Parasites

Consequences, Molecular Mechanisms and Possible Treatments

  • Contains new chapters on metabolism

  • Provides detailed information on basic principles of and new findings in Leishmania and Leishmaniasis

  • Multi-authored with contributions of interest for both individuals in academic fields and industry

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eBook USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-74186-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 179.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvii
  2. Leishmaniasis: The Biology of a Parasite

    • Emilia Díaz, Alicia Ponte-Sucre
    Pages 1-16
  3. Determinant Features in Leishmaniasis

    1. Front Matter

      Pages 17-17
    2. Molecular Evolution and Phylogeny of Leishmania

      • Gabriele Schönian, Julius Lukeš, Olivia Stark, James A. Cotton
      Pages 19-57
    3. The Role of Reservoirs: Canine Leishmaniasis

      • Lenea Campino, Carla Maia
      Pages 59-83
    4. The Role of the Immune System in Resistance to Infection

      • Lukasz Kedzierski, Krystal J. Evans
      Pages 109-142
  4. Challenges in the Diagnosis, Treatment and Control of Leishmaniasis in Times of Drug Resistance

    1. Front Matter

      Pages 143-143
    2. Co-infection with HIV

      • Margriet den Boer, Jorge Alvar
      Pages 145-158
    3. Visceral Leishmaniasis

      • Shyam Sundar, Jaya Chakravarty
      Pages 159-176
    4. American Tegumentary Leishmaniasis

      • Olga Zerpa, Maritza Padrón-Nieves, Alicia Ponte-Sucre
      Pages 177-191
    5. The Challenges of Effective Leishmaniasis Treatment

      • Sarah Hendrickx, Louis Maes, Simon L. Croft, Guy Caljon
      Pages 193-206
  5. Molecular Features of Drug Resistant Leishmania

    1. Front Matter

      Pages 207-207
    2. The Role of Proteomics in the Study of Drug Resistance

      • Leonardo Saboia-Vahia, Jose Batista de Jesus, Patricia Cuervo
      Pages 209-245
    3. The Role of ABC Transporters in Drug-Resistant Leishmania

      • Adriano C. Coelho, Paulo C. Cotrim
      Pages 247-272
  6. Tools and Strategies to Circumvent Drug Resistance in Leishmania

    1. Front Matter

      Pages 295-295
    2. Bioinformatics in Leishmania Drug Design

      • Shishir K. Gupta, Thomas Dandekar
      Pages 297-317
    3. The Concept of Fitness in Leishmania

      • Manu Vanaerschot, Franck Dumetz, Marlene Jara, Jean-Claude Dujardin, Alicia Ponte-Sucre
      Pages 341-366

About this book

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide.

Keywords

  • ABC Transporters
  • Drug Resistance
  • Infectious Disease
  • Leishmaniasis
  • Parasite
  • Vaccine Development
  • antibacterial drug resistance
  • infectious diseases
  • vaccines

Reviews

“The chapters in this book are appropriate for beginning students and seasoned Leishmania researchers alike. … This could serve as an excellent foundation for those who are new to the field of Leishmania and a tremendous source of reference for more advanced researchers. It is well organized, chapters are well written and referenced, and there is minimal overlap between chapters.” (Ivy Hurwitz, Doody's Book Reviews, August 16, 2019)

Editors and Affiliations

  • Institute of Experimental Medicine, Universidad Central de Venezuela, Caracas, Venezuela

    Alicia Ponte-Sucre

  • Escuela Luis Razetti Fac de Medicine, Universidad Central de Venezuela, Caracas, Venezuela

    Maritza Padrón-Nieves

About the editors

Professor Dr. Maritza Padrón Nieves

Maritza Padrón Nieves studied Biology at UCV in Caracas and became Magister Scientiarum in Pharmacology in 1993 and Doctor of Sciences in Pharmacology in 2011 in the same university. From 1994 to 2000 she was head of the Department of Basic Sciences at the School of Nursery, UCV. Currently she is Full Professor and head of the Human Pharmacology and Toxicology Chair, Faculty of Medicine, UCV. Initially her research interests were related to the comprehension of the mechanisms involved in digoxin intoxication. Since 2006 she has dedicated her scientific interest to the identification and characterization of molecular markers of resistance in the Leishmania sp. infection model.

Professor Dr. Alicia Ponte-Sucre

Alicia Ponte-Sucre studied Education in Biological Sciences at the Andrés Bello Catholic University in Caracas and became Magister Scientiarum in Physiology and Biophysics in 1981 at the Venezuelan Institute of Scientific Research and Doctor of Sciences in Pharmacology in 1993 at the UCV. She spent a year (1999-2000) at the University of Würzburg with a scholarship from the Alexander von Humboldt Foundation and was a staff scientist (2003-2007) at the same university, within a multidisciplinary project from the German Research Council. Currently she is Full Professor in Human Physiology and Coordinator for Scientific Affairs of the Faculty of Medicine, UCV. Initially, her studies were focused on the physical-chemical behavior of black lipid membranes. Later, her scientific activity was oriented towards the characterization of receptors involved in air-way smooth muscle contraction. During the last 30 years her interests have been focused towards the study of parasite metabolism and membrane transporters essential for parasite survival and involved in drug resistance, and the mechanisms involved in cellular differentiation and parasite-host interaction in Trypanosomatids, but especially in the Leishmania model. Additionally she has characterized natural products and target oriented designed compounds as potential therapeutic agents against diseases produced by these parasites.

Bibliographic Information

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-74186-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 179.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)