Biomarkers in Neoplastic Neuropathology

  • Fausto Rodriguez
  • Cheng-Ying Ho

Table of contents

  1. Front Matter
    Pages i-x
  2. Fausto Rodriguez, Cheng-Ying Ho
    Pages 1-9
  3. Fausto Rodriguez, Cheng-Ying Ho
    Pages 11-44
  4. Fausto Rodriguez, Cheng-Ying Ho
    Pages 45-52
  5. Fausto Rodriguez, Cheng-Ying Ho
    Pages 53-58
  6. Fausto Rodriguez, Cheng-Ying Ho
    Pages 59-98

About this book

Introduction

This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.

Keywords

Brain Tumor Gene Expression Profiling Immunohistochemistry Neurooncology Next generation sequencing

Authors and affiliations

  • Fausto Rodriguez
    • 1
  • Cheng-Ying Ho
    • 2
  1. 1.PathologyJohns Hopkins UniversityBaltimoreUSA
  2. 2.PathologyChildren’s National Medical CenterWashington, D.C.USA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-20931-9
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-20930-2
  • Online ISBN 978-3-319-20931-9
  • About this book
Industry Sectors
Biotechnology
Consumer Packaged Goods
Pharma