Overview
- Nominated as an outstanding PhD thesis by Aarhus University, Denmark
- Provides a comprehensive review of the general amyloid literature, in particular that on human islet amyloid polypeptide
- Includes detailed illustrations, which significantly aid in the understanding of amyloid proteins and the research presented
- Combines theoretical and experimental research to deliver a high-impact, high-quality contribution
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (7 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.
Authors and Affiliations
About the author
Katrine Skeby was accepted into the prestigious honors PhD programme at Aarhus University directly following the completion of her Bachelor's degree in medicinal chemistry. During her PhD studies she has won multiple prizes and grants and has made a significant contribution to the field of amyloid research. Following the completion of her PhD, Katrine was awarded a postdoctoral scholarship from the Carlsberg Foundation to study how molecular dynamics simulations can be used to visualize molecular motion in animation. She is conducting this work at the world-leading scientific animation company, Digizyme Inc., led by Prof. at Harvard Medical School, Gaël McGill.
Bibliographic Information
Book Title: Computational Modelling of the Human Islet Amyloid Polypeptide
Authors: Katrine Kirkeby Skeby
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-20040-8
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-20039-2Published: 03 June 2016
Softcover ISBN: 978-3-319-79293-4Published: 26 May 2018
eBook ISBN: 978-3-319-20040-8Published: 27 May 2016
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XVI, 118
Number of Illustrations: 11 b/w illustrations, 47 illustrations in colour
Topics: Medicinal Chemistry, Computer Applications in Chemistry, Bioorganic Chemistry
Industry Sectors: Biotechnology