Plasma Cell Neoplasms

1. Front Matter

   Pages i-x

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2. Clinical Protein and Immunofixation Electrophoresis

   • Jonathan R. Genzen

   Pages 1-23

3. Serum Free Light Chain Analysis

   • Rajeevan Selvaratnam, Jing Cao, Amy B. Karger

   Pages 25-42

4. Plasma Cell Neoplasms: Morphology and Immunohistochemistry

   • Garth Aasen, Robert W. McKenna

   Pages 43-64

5. Classification of Plasma Cell Neoplasms

   • Sophia L. Yohe

   Pages 65-78

6. Conventional and Molecular Cytogenetics in Plasma Cell Neoplasms

   • Michelle Dolan

   Pages 79-99

7. Role of Flow Cytometry in Plasma Cell Neoplasms

   • Beenu Thakral, Kristy Wolniak, Michael A. Linden

   Pages 101-122

8. Plasma Cell Neoplasms, A Therapeutic Approach

   • Brian L. McClune, Sagar S. Patel

   Pages 123-141

9. Standardized Synoptic Reports for Plasma Cell Neoplasms: Integration of Laboratory and Clinical Data

   • Elizabeth L. Courville, Zohar Sachs, Michael A. Linden

   Pages 143-149

10. Back Matter

    Pages 151-152

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This volume provides a comprehensive, state-of-the art review on the field of diagnostic hematopathology as it is applied to patients with plasma cell neoplasms. The book places particular emphasis on immunophenotypic data – immunohistochemistry and flow cytometry – as well as cytogenetics, and discusses how these ancillary data can predict prognosis and chemotherapeutic response. It also provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

 Written by experts in their fields, Plasma Cell Neoplasms serves as a very useful resource for physicians and researchers interested in plasma cell myeloma diagnosis, therapy, and research.  

 

• cytogenetics
• electrophoresis
• immunofixation
• immunohistochemistry
• plasma cell myeloma
• synoptic reporting

• and Pathology, University of Minnesota Department of Laboratory Medicine, Minneapolis, USA

  Michael A. Linden, Robert W. McKenna

Dr. Linden is an Assistant Professor in the Division of Hematopathology within the Department of Laboratory Medicine and Pathology. In addition, he is the Assistant Director of the Special Hematology Laboratory. As a graduate student, Dr. Linden’s thesis work helped develop a new mouse model of multiple myeloma. Dr. Linden completed residency and fellowship training in Hematopathology at the University of Washington. He now attends on the University of Minnesota Medical Center’s Hematopathology and Flow Cytometry services. Dr. Linden continues to have a strong interest in plasma cell and other hematopoietic neoplasms and enjoys research that applies his clinical skills to improving clinical laboratory diagnoses and predicting clinical outcomes. More specifically, he is investigating optimum diagnostic methods for monitoring residual disease in myeloma patients and developing diagnostic tests to predict chemotherapeutic sensitivity of the neoplastic plasma cells. In addition, he greatly values resident/fellow education and mentorship.