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Gene Therapy in Inflammatory Diseases

  • Book
  • © 2000

Overview

Editors:
  1. Christopher H. Evans

    1. Center for Molecular Orthopaedics, Harvard Medical School, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Paul D. Robbins

    1. University of Pittsburgh School of Medicine, Pittsburgh, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xii
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  2. Gene therapy for inflammatory diseases — basic concepts

    • Christopher H. Evans, Paul D. Robbins
    Pages 1-11

  3. Gene therapy for rheumatoid arthritis: preclinical studies

    • Sergei S. Makarov
    Pages 13-34

  4. Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model

    • Thomas Pap, Ulf Müller-Ladner, Klaus M. Hummel, Renate E. Gay, Steffen Gay
    Pages 35-51

  5. Gene therapy for rheumatoid arthritis: clinical studies

    • Thomas S. Muzzonigro, Richard Kang, Julio Reinecke, Peter Wehling, Mary C. Wasko, James H. Herndon
    Pages 53-63

  6. Cytokine gene therapy of allergic airways inflammation

    • Alistair J. Ramsay, Simon P. Hogan, Paul S. Foster, Yelin Xiong
    Pages 65-81

  7. Gene therapy for inflammatory diseases of the salivary glands

    • Philip C. Fox, Brian C. O’Connell
    Pages 83-93

  8. Gene therapy for management of lupus: Correction of Fas and Fas ligand-induced apoptosis in murine disease — therapeutic rationale and strategies

    • Huang-Ge Zhang, Martin Fleck, Hui-Chen Hsu, Carl K. Edwards III, David T. Curiel, Tong Zhou et al.
    Pages 95-117

  9. Gene therapy for multiple sclerosis

    • Michael K. Shaw, Richard DalCanto, C. Garrison Fathman
    Pages 119-131

  10. Gene therapy for type I diabetes mellitus

    • Nick Giannoukakis, Massimo Trucco, Paul D. Robbins
    Pages 133-162

  11. Gene transfer to facilitate transplantation

    • Jonathan S. Bromberg, Lisa A. DeBruyne, Randall S. Sung, Lihui Qin
    Pages 163-204

  12. DNA vaccination as an anti-inflammatory strategy

    • Alexis Paul Godillot, Michael Madaio, David B. Weiner, William V. Williams
    Pages 205-229

  13. Naked DNA as a gene delivery vehicle in inflammatory diseases

    • Masayuki Miyata, Yukio Sato, Reiji Kasukawa
    Pages 231-239

  14. Animal models of arthritis generated by gene transfer

    • Steven C. Ghivizzani, Eric R. Lechman, Daniel Jaffurs, Zhibao Mi, Richard Kang, Thomas S. Muzzonigro et al.
    Pages 241-255

  15. Back Matter

    Pages 256-260
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Keywords

About this book

Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

Editors and Affiliations

  • Center for Molecular Orthopaedics, Harvard Medical School, Boston, USA

    Christopher H. Evans

  • University of Pittsburgh School of Medicine, Pittsburgh, USA

    Paul D. Robbins

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