Abstract
The systemic injection of cytokines and related peptide is being used therapeutically with increasing success in animal models of inflammatory diseases. However, its applications are limited, because of the need for large amounts of purified proteins and the short-lived effects of these proteins. As described in the chapter by Evans and Robbins, this volume, gene transfer strategies offer novel possibilities for overcoming these limitations.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, Lotz M Kipps TJ, Carson DA (1993) Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci USA 90: 4523–4527
Raz E, Dudler J, Lotz M, Baird SM, Berry CC, Eisenberg RA, Carson DA (1995) Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 4: 286–292
Giladi E, Raz E, Karmeli F, Okon E, Rachmilewitz D (1995) Transforming growth factor-β gene therapy ameliorates experimental colitis in rats. Eur J Gastro Hepatology 7: 341–347
Daheshia M, Kuklin N, Kanangat S, Manickan E, Rouse BT (1997) Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10. J Immunol 159: 1945–1952
Miyata M, Sato Y, Sato H, Saito A, Irisawa A, Nishimaki T, Kasukawa R (1997) Suppression of murine collagen-induced arthritis by inoculation of plasmid DNA encoding for interleukin-10. Arthritis Rheum 40: S55
Czarniecki CW Chiu HH, Wong GHW, McCabe SM, Palladino MA (1988) Transforming growth factor-1 modulates the expression of class II histocompatibility antigens on human cells. J Immunol 140: 4217–4223
Niemialtowski MG, Rouse BT (1992) Predominance of Th1 cells in ocular tissue during herpetic stromal keratitis. J Immunol 149: 3035–3039
Hendricks RL, Tumpey TM, Finnegan A (1992) IFG-γ and IL-2 are protective in the skin but pathogenic in the corneas of HSV-1 infected mice. J Immunol 149: 3023–3028
Tumpey TM, Elner VM, Chen S, Oakes JE, Lausch RN (1994) Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. J Immunol 153: 2258–2265
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Basel AG
About this chapter
Cite this chapter
Miyata, M., Sato, Y., Kasukawa, R. (2000). Naked DNA as a gene delivery vehicle in inflammatory diseases. In: Evans, C.H., Robbins, P.D. (eds) Gene Therapy in Inflammatory Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8478-5_12
Download citation
DOI: https://doi.org/10.1007/978-3-0348-8478-5_12
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9584-2
Online ISBN: 978-3-0348-8478-5
eBook Packages: Springer Book Archive