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  • Book
  • Open Access
  • © 2020

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

  • First comprehensive book on factors associated with high risk for poor reproducibility of non-clinical findings

  • Inclusion of aspects of study design, data analysis and data reporting

  • Broad applicability to in vitro and in vivo research across all therapeutic areas

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 257)

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)

Table of contents (21 chapters)

  1. Front Matter

    Pages i-x
  2. Quality in Non-GxP Research Environment

    • Sandrine Bongiovanni, Robert Purdue, Oleg Kornienko, René Bernard
    Pages 1-17Open Access
  3. Guidelines and Initiatives for Good Research Practice

    • Patricia Kabitzke, Kristin M. Cheng, Bruce Altevogt
    Pages 19-34Open Access
  4. Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices

    • Isabel A. Lefevre, Rita J. Balice-Gordon
    Pages 35-54Open Access
  5. General Principles of Preclinical Study Design

    • Wenlong Huang, Nathalie Percie du Sert, Jan Vollert, Andrew S. C. Rice
    Pages 55-69Open Access
  6. Blinding and Randomization

    • Anton Bespalov, Karsten Wicke, Vincent Castagné
    Pages 81-100Open Access
  7. Quality of Research Tools

    • Dario Doller, Paul Wes
    Pages 119-145Open Access
  8. Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies

    • Stacey J. Sukoff Rizzo, Stephanie McTighe, David L. McKinzie
    Pages 147-162Open Access
  9. Building Robustness into Translational Research

    • Betül R. Erdogan, Martin C. Michel
    Pages 163-175Open Access
  10. Minimum Information and Quality Standards for Conducting, Reporting, and Organizing In Vitro Research

    • Christoph H. Emmerich, Christopher M. Harris
    Pages 177-196Open Access
  11. Minimum Information in In Vivo Research

    • Patrizia Voehringer, Janet R. Nicholson
    Pages 197-222Open Access
  12. A Reckless Guide to P-values

    • Michael J. Lew
    Pages 223-256Open Access
  13. Electronic Lab Notebooks and Experimental Design Assistants

    • Björn Gerlach, Christopher Untucht, Alfred Stefan
    Pages 257-275Open Access
  14. Data Storage

    • Christopher Frederick Isambard Blumzon, Adrian-Tudor Pănescu
    Pages 277-297Open Access
  15. Design of Meta-Analysis Studies

    • Malcolm R. Macleod, Ezgi Tanriver-Ayder, Kaitlyn Hair, Emily Sena
    Pages 299-317Open Access
  16. Quality Governance in Biomedical Research

    • Anja Gilis
    Pages 349-365Open Access
  17. Good Research Practice: Lessons from Animal Care and Use

    • Javier Guillén, Thomas Steckler
    Pages 367-382Open Access

About this book

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.


  • reproducibility
  • study design
  • data analysis
  • data reporting
  • data integrity
  • quality management
  • open access

Editors and Affiliations

  • Partnership for Assessment & Accreditation of Scientific Practice, Heidelberg, Germany

    Anton Bespalov

  • Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany

    Martin C. Michel

  • Janssen Pharmaceutica N.V., Beerse, Belgium

    Thomas Steckler

Bibliographic Information

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)