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Gene Expression in Normal and Transformed Cells

  • Book
  • © 1983

Overview

Editors:
  1. J. E. Celis

    1. Aarhus University, Aarhus, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  2. R. Bravo

    1. EMBL Laboratory, Heidelberg, Federal Republic of Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 64)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-ix
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  2. Differentiation Models and Gene Expression in Differentiated Cells

    1. Molecular Approach to the Study of Neural Function and Differentiation

      • M. M. Portier, B. Croizat, F. Berthelot, B. Edde, D. Paulin, F. Gros
      Pages 1-43

    2. Cellular Systems and Aspects of Protein Synthesis in the Study of Muscle Cell Differentiation

      • R. G. Whalen
      Pages 45-69

    3. Organization of Muscle-Specific Genes in the Rodent Genome

      • H. Czosnek, Y. Carmon, M. Shani, U. Nudel, P. E. Barker, F. H. Ruddle et al.
      Pages 71-85

    4. Approaches To the Biochemistry of Differentiation of Mouse Embryonal Carcinoma Cells

      • M. J. Evans, R. H. Lovell-Badge, D. Latchman, A. Stacey, H. Brzeski
      Pages 87-99

    5. Changes of Protein Glycosylation During Differentiation of Mouse Embryonal Carcinoma Cells

      • G. Cossu, L. Warren
      Pages 101-116

    6. Focusing on a Particular Model of Cell Differentiation: The Vertebrate Eye Lens

      • L. Simmonneau
      Pages 117-139

  4. Viral Oncogenesis

    1. The Molecular Genetics of Avian Erythroblastosis Virus

      • M. L. Privalsky, L. Sealy, B. Vennstrom, J. M. Bishop
      Pages 193-208

    2. Protein Kinases Specific for Tyrosine Residues and the Role of Tyrosine Phosphorylation of Proteins in Cell Transformation

      • J. Ghysdael
      Pages 209-230

    3. Enzootic Bovine Leukosis and Bovine Leukemia Virus

      • G. Marbaix, R. Kettmann, J. Deschamps, D. Couez, M. Mammerickx, A. Burny
      Pages 231-245

    4. Gene Transfer into Culture Cells and its Application to Study Cell Transformation

      • A. Graessmann, M. Graessmann
      Pages 247-261

  5. Gene Expression in Normal and Transformed Cells

    1. Expression of Cellular Protein in Normal and Transformed Human Cultured Cells

      • R. Bravo, J. Bellatin, S. J. Fey, P. Mose Larsen, J. E. Celis
      Pages 263-290

    2. Polypeptide Synthesis in Human Sarcoma and Normal Tissue

      • J. Forchhammer, H. Macdonald-Bravo
      Pages 291-314

    3. The Reversible Modulation of the Synthesis of Matrix Components in Definitive Chondroblasts Transformed by a ts-Rous Sarcoma Virus Mutant

      • M. Pacifici, S. L. Adams, H. Holtzer, D. Boettiger
      Pages 315-348

    4. Proteins Affected by Chromosome 21 and Ageing In Vitro

      • M. L. Van Keuren, C. R. Merril, D. Goldman
      Pages 349-378

    5. Variation in Expression of Human Major Histocompatibility Genes in Mouse L Cells After DNA-Mediated Gene Transfer

      • J. A. Barbosa, M. E. Kamarck, F. H. Ruddle
      Pages 379-401

    6. Expression of Development-Phase Specific Alkaline Phosphatase Isoenzymes in Cultured Cancer Cells

      • W. H. Fishman
      Pages 403-414

    7. Nonhistone Protein Antigens in Rat Hepatomas

      • L. S. Hnilica, W. N. Schmidt, R. C. Briggs
      Pages 415-431
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Keywords

About this book

This volume is based on the proceedings of a NATO-Gulbenkian Foundation sponsored Summer School held in May-June 1982 in Sintra­ Estoril, Portugal. Given the accelerated growth of knowledge in the field of eukaryotic gene expression, it seemed timely to hold a NATO Advanced Study Institute to discuss current developments in this area of biology and to evaluate the potential of emerging technologies such as gene transfer, recombinant DNA cloning and quantitative high resolution two-dimensional gel electrophoresis. The initial articles in t~is volume describe various differentiation models and address questions such as the relationships between differentiation and cell proliferation, biochemical changes accompanying differen­ tiation, expression of differentiated gene products and their regulation as well as gene organization of cytoskeletal proteins. The second section describes properties of neoplastic cells, surveys current assays for transformation and offers some new insights into the mechanisms involved in carcinogenesis. The third part is dedicated to viral oncogenesis and to the role of onco­ genes in cell transformation. Particular emphasis is given to the role of tyrosine kinases in cell transformation. The concluding section deals with various aspects of gene expression in normal and transformed cells with special emphasis given to studies using two dimensional gel electrophoresis, cell hybridization, gene transfer and immunological techniques.

Editors and Affiliations

  • Aarhus University, Aarhus, Denmark

    J. E. Celis

  • EMBL Laboratory, Heidelberg, Federal Republic of Germany

    R. Bravo

Bibliographic Information

  • Book Title: Gene Expression in Normal and Transformed Cells

  • Editors: J. E. Celis, R. Bravo

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-4541-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1983

  • Softcover ISBN: 978-1-4684-4543-5Published: 15 April 2013

  • eBook ISBN: 978-1-4684-4541-1Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: IX, 441

  • Number of Illustrations: 147 b/w illustrations

  • Topics: Human Genetics

  • Industry Sectors: Biotechnology, Pharma

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