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Gene Expression in Normal and Transformed Cells pp 349–378Cite as

Proteins Affected by Chromosome 21 and Ageing In Vitro

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Abstract

An extra copy of chromosome 21 is the cause of the disorder known as Down syndrome. The mechanisms underlying the pathogenesis of this syndrome are unknown. Some of the features of Down syndrome are mental retardation, a high incidence of cardiac defects and predisposition for development of acute myeloblasts and acute lymphocytic leukemia (1). Individuals with this disorder display features of premature ageing (2, 3); those who survive into their 30’s and 40’s express dementia, accompanied by neuropathological features identical to those found in Alzheimer’s disease (4–6).

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Author information

Author notes

  1. M. L. Van Keuren

    Present address: E. Roosevelt Inst. for Cancer Res., Box B-129, 4200 East Ninth Av., Denver, Colo., 80262, USA

Authors and Affiliations

  1. Laboratory of General and Comparative Biochemistry, Bethesda, Maryland, 20205, USA

    M. L. Van Keuren & C. R. Merril

  2. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    D. Goldman

Authors
  1. M. L. Van Keuren
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  2. C. R. Merril
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  3. D. Goldman
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Editor information

Editors and Affiliations

  1. Aarhus University, Aarhus, Denmark

    J. E. Celis

  2. EMBL Laboratory, Heidelberg, Federal Republic of Germany

    R. Bravo

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© 1983 Plenum Press, New York

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Van Keuren, M.L., Merril, C.R., Goldman, D. (1983). Proteins Affected by Chromosome 21 and Ageing In Vitro . In: Celis, J.E., Bravo, R. (eds) Gene Expression in Normal and Transformed Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4541-1_16

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  • DOI: https://doi.org/10.1007/978-1-4684-4541-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4543-5

  • Online ISBN: 978-1-4684-4541-1

  • eBook Packages: Springer Book Archive

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