• Roger G. Pertwee

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 168)

Table of contents

  1. Front Matter
    Pages I-XII
  2. R. G. Pertwee
    Pages 1-51
  3. A. C. Howlett
    Pages 53-79
  4. V. Di Marzo, T. Bisogno, L. De Petrocellis
    Pages 147-185
  5. G. A. Thakur, S. P. Nikas, C. Li, A. Makriyannis
    Pages 209-246
  6. B. Szabo, E. Schlicker
    Pages 327-365
  7. C. W. Vaughan, M. J. Christie
    Pages 367-383
  8. G. A. Cabral, A. Staab
    Pages 385-423
  9. K. P. Lindsey, S. T. Glaser, S. J. Gatley
    Pages 425-443
  10. G. Riedel, S. N. Davies
    Pages 445-477
  11. J. Fernández-Ruiz, S. González
    Pages 479-507
  12. J. M. Walker, A G. Hohmann
    Pages 509-554
  13. A. A. Izzo, A. A. Coutts
    Pages 573-598
  14. P. Pacher, S. Bátkai, G. Kunos
    Pages 599-625
  15. M. Guzmán
    Pages 627-642
  16. J. A. Ramos, M. Gómez, R. de Miguel
    Pages 643-656
  17. A. H. Lichtman, B. R. Martin
    Pages 691-717
  18. Back Matter
    Pages 757-770

About this book


Less than 20 years ago the ?eld of cannabis and the cannabinoids was still c- sidered a minor, somewhat quaint, area of research. A few groups were active in the ?eld, but it was already being viewed as stagnating. The chemistry of cannabis 9 9 was well known, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several s- thetic analogs had been thoroughly investigated for their pharmacological effects. Their mode of action was considered to be non-speci?c. The reasons for this - sumption were both technical and conceptual. On the technical side, it had been shown that THC was active in both enantiomeric forms (though with a different level of potency) and this observation was incompatible with action on biological substrates—a receptor, an enzyme, an ion channel—which react with a single stereoisomer only. The conceptual problem related to THC activity. This had been pointed out by several highly regarded research groups that had shown that many of the effects seen with cannabinoids were related to those of biologically active lipophiles, and that many of the effects of THC, particularly chronic ones, were comparable to those seen with anaesthetics and solvents.


Cannabinoid Nervous System cannabinoid mechanisms of pain suppression cannabinoid receptors and their ligands endocannabinoids molecular biology and signalling of cannabinoid receptors physiology

Editors and affiliations

  • Roger G. Pertwee
    • 1
  1. 1.School of Medical Sciences, Institute of Medical ScienceUniversity of AberdeenAberdeenUK

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