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Evolution-adjusted Tumor Pathophysiology:

The Novel Language of Tumor Biology

  • Book
  • © 2013

Overview

Editors:
  1. Albrecht Reichle

    1. , Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany

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  • Applied systems biology
  • Personalizing tumor therapy with novel methodological approaches
  • Drafting the non-genomic counterpart of the genome: Rationalizations constituting tumor-associated normative notions (angiogenesis, inflammation, immune response etc.)
  • Reconstructing and operationalizing starting points for an evolution theory
  • Evolution-adjusted tumor pathophysiology as novel clinical and pharmaceutical technology for bioengineering tumor response

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Table of contents (23 chapters)

  2. Reconstruction of Tumor-Immanent Normative Functions, Structures and Decision Maxims (Hubs)

    1. Front Matter

      Pages 301-301
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    2. Bridging a Diagnostic and Therapeutic Gap: Selecting, Assessing and Categorizing, Tumor-associated Normative Notions

      • Albrecht Reichle
      Pages 303-321

    3. Personalizing Tumor Pathophysiology by Diagnosing Developmental Problems in Tumors with Imaging Techniques

      • Fabian Kiessling, Wiltrud Lederle
      Pages 323-341

    4. Biologic Memory: Induction by Metronomically Administered Combined Modularized Therapy

      • M. Vogelhuber, C. Hart, M. Grube, A. Reichle
      Pages 343-361

  3. The Tool of Rationalizations Constituting Tumor-Associated Normative Notions: The Non-Genomic Counterpart of the Tumor Genome and Therefore, an Important Therapeutic Target for Diversifying Palliative Care

    1. Front Matter

      Pages 363-363
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    2. Diversifying and Specifying Palliative Care for Patients with Metastatic Cancer by Therapeutic Implementation of Non-Normative Boundary Conditions

      • Albrecht Reichle, Gerhard C. Hildebrandt
      Pages 365-395

    3. Targeting a Hallmark of Cancer: Simultaneous Inflammation and Tumor Control for Palliative Care in Metastatic Cancer

      • J. Pfirstinger, A. Reichle, J. Grassinger
      Pages 397-415

  4. Novel Clinical and Pharmaceutical Technology for Bioengineering Tumor Response

    1. Front Matter

      Pages 417-417
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    2. Combined Modularized Tumor Therapy—Tumor Biology—and Prognostic Factors: Bioengineering Tumor Response

      • Albrecht Reichle
      Pages 419-429

  5. Objectifying the Systems Objects’ Subjectivity in Biological Systems: A Novel Reification of the Scientific Picture About the ‘Objective’ World

    1. Front Matter

      Pages 431-431
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  6. Objectifying the Systems Objects’ Subjectivity in Biological Systems: A Novel Reification of the Scientific Picture About the ‘Objective’ World

    1. The Subjectivity of Systems Objects as a Scientific Object

      • Albrecht Reichle
      Pages 433-438

  7. Back Matter

    Pages 439-453
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Keywords

About this book

Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.

Editors and Affiliations

  • , Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany

    Albrecht Reichle

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