Early administration of hydrocortisone replacement after advent of septic shock is a major determinant of final outcome
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KeywordsPublic Health Regression Analysis Hydrocortisone Septic Shock Emergency Medicine
The CORTICUS trial doubts the value of hydrocortisone replacement for final outcome of septic shock . We hypothesized that the time of starting hydrocortisone may impact on the final outcome.
Retrospective analysis was made of prospectively collected data for 41 patients with septic shock (ACCP/SCCM 1992 definition) in the past year in two ICUs. Hydrocortisone was infused as suggested . The time lapsing from start of vasopressors until start of hydrocortisone was determined by the patients' charts.
Despite the observational approach, early start of hydrocortisone replacement in septic shock is a critical factor for outcome.
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