Desmopressin improves intestinal functional capillary density and decreases leucocyte activation in experimental endotoxemia in the rat
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KeywordsVasopressin Desmopressin DDAVP Microvascular Perfusion Functional Capillary Density
The vasopressin analogue desmopressin (DDAVP), a selective agonist of the vasopressin V2 receptor, is known to cause vasodilatation in addition to its haemostatic effects. To verify whether desmopressin could be beneficial in sepsis we investigated its effects on intestinal microcirculation in experimental endotoxemia in rats.
In Lewis rats (six groups, 10 animals each) the effects of vasopressin (VAS) (0.06 U/340 g/minute) and DDAVP (1 μg/kg/ml) on the terminal ileum microcirculation 2 hours after introducing endotoxemia (5 mg/kg lipopolysaccharide (LPS), i.v.) were examined using intravital fluorescence microscopy.
Desmopressin administration improved microvascular perfusion and reduced inflammatory response in experimental endotoxemia.
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