Endothelial glycocalyx disruption after cardiac surgery in infants
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KeywordsCongenital Heart Disease Congenital Heart Cardiopulmonary Bypass Systemic Inflammation Biochemical Marker
The endothelial glycocalyx (EGX) modulates vascular permeability and inflammation. It is disrupted by ischaemia-reperfusion. We hypothesised that cardiopulmonary bypass would elevate markers of EGX shedding, which would be associated with increased postoperative inflammation.
A prospective cohort of 25 infants (median weight 5 kg) undergoing surgery for congenital heart disease. Blood temporal pro-files of two markers of EGX disruption - heparan sulphate (HEP) and syndecan-1 (SYND) - were correlated with a biochemical marker of systemic inflammation (IL-6) and clinical outcome variables.
Although markers of EGX disruption show a reproducible temporal profile after bypass, the lack of correlation with IL-6 and clinical markers means that their significance is unclear.
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