Endothelial glycocalyx disruption after cardiac surgery in infants
- 627 Downloads
KeywordsCongenital Heart Disease Congenital Heart Cardiopulmonary Bypass Systemic Inflammation Biochemical Marker
The endothelial glycocalyx (EGX) modulates vascular permeability and inflammation. It is disrupted by ischaemia-reperfusion. We hypothesised that cardiopulmonary bypass would elevate markers of EGX shedding, which would be associated with increased postoperative inflammation.
A prospective cohort of 25 infants (median weight 5 kg) undergoing surgery for congenital heart disease. Blood temporal pro-files of two markers of EGX disruption - heparan sulphate (HEP) and syndecan-1 (SYND) - were correlated with a biochemical marker of systemic inflammation (IL-6) and clinical outcome variables.
Although markers of EGX disruption show a reproducible temporal profile after bypass, the lack of correlation with IL-6 and clinical markers means that their significance is unclear.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.