Cardiac output augmentation with fluid resuscitation improves brain tissue oxygenation after severe brain injury
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KeywordsCardiac Output Fluid Resuscitation Cerebral Oxygenation Stroke Volume Variation Fluid Challenge
The objective of this study was to investigate the relationship between cardiac output response to a fluid challenge and changes in brain tissue oxygen pressure (PbtO2) in patients with severe brain injury.
Prospective observational study conducted in a neurological ICU in a university hospital. Seventy-eight fluid challenges were administered to 17 consecutive comatose patients that underwent multimodality monitoring of cardiac output, intracranial pressure (ICP), and PbtO2. The relationship between cardiac output and PbtO2 was analyzed with logistic regression utilizing GEE with an exchangeable correlation structure.
Bolus fluid resuscitation resulting in augmentation of cardiac output can improve cerebral oxygenation after severe brain injury.