C-reactive protein predicts mortality on admission to a surgical high-dependency unit
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KeywordsPublic Health Inflammatory Response Emergency Medicine Powerful Predictor Temporal Relationship
C-reactive protein (CRP) is a non-specific marker that may be used to assess the magnitude of the inflammatory response in critically ill surgical patients. Our aim was to determine the temporal relationship between CRP measurement and mortality.
In a prospective study conducted in a surgical high-dependency unit (HDU), 132 consecutive patients were evaluated. Regional Ethics Committee approval was obtained. Serum CRP was measured on admission, day 1 and day 2 and was evaluated with respect to inhospital mortality.
CRP <100 mg/l
CRP >100 mg/l
2.2% (n = 93)
25.6% (n = 39)
CRP on admission to the surgical HDU is a powerful predictor of mortality (P < 0.0001), but this correlation does not persist after the initial measurement. Our data suggest that early CRP measurement should be undertaken in all critically ill surgical patients in order to quantify the ultimate magnitude of the inflammatory response and the associated mortality.