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Critical Care

, 7:P018 | Cite as

Relationship between platelet counts, C-reactive protein and plasma fibrinolytic capacity in critically ill patients

  • K Zouaoui Boudjeltia
  • M Piagnerelli
  • E Carlier
  • S Jamart
  • Ph Cauchie
  • M Vanhaeverbeek
Meeting abstract
  • 2.5k Downloads

Keywords

Platelet Count Fibrinogen Endothelium Dysfunction Inflammatory Marker Biological Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

Multiple Organ Failure (MOF) complicating the sepsis remains the first cause of death in the ICU. A recent study showed that vascular endothelial damage was the primary cause of MOF in patients with thrombopenia and that humoral mediators played a major role in the development of this process [1]. Other parameters like C-protein reactive were also probably important via a direct effect on endothelial cells and increasing the secretion of IL-6. In this study, we aimed to evaluate the relation between the platelet counts (PC), the C-reactive protein and plasma fibrinolytic capacity (as a marker of endothelium dysfunction) in ICU patients.

Methods

We studied blood samples of ICU patients with (n = 11) and without (n = 21) sepsis at the first day of admission. Fibrinolytic capacity was evaluated by the Euglobulin Clot Lysis Time (ECLT) determined by a new method [2]. We also collected biological data and the SAPS II score for each patients. The correlations were depicted by Spearman's test.

Results

The ECLT was significantly correlated with CRP (R = 0.64; P < 0.001) and PC (R = -0.4; P = 0.02). The two-way ANOVA showed that the sepsis status increased significantly the ECLT (P = 0.023) and that platelets under 208,500 cells/μl (median of the histogram of PC was used as the cut-off) also increased the ECLT (P = 0.023). However, there was no interaction (P = 0.184).

Conclusion

Platelets can protect the endothelium against several forms of oxidative injuries [3]. With this study we showed that the decrease of the platelets count could favor the endothelium dysfunction and impaired fibrinolytic capacity, and this independently of sepsis. In addition, C-reactive protein is not only an inflammatory marker, but it might be involved in the endothelium damage.
 

Sepsis (n = 11)

Nonsepsis (n = 21)

P value

CRP (mg%)

25 (17–30)

6.9 (2.1–11.6)

< 0.001

WBC (× 103 cells/μl)

10.5 (7.7–12.9)

9.8 (8–12)

0.69

Fibrinogen (mg%)

662 (597–686)

455 (333–542)

< 0.001

SAPS

48 (39–56)

23 (15–35)

0.003

Platelets (× 103 cells/μl)

186 (123–227)

229 (179–296)

0.17

ECLT (min)

987 (845–1375)

599 (477–950)

0.01

Data presented as median (25–75%).

References

  1. 1.
    Hirokazu U, et al.: Crit Care Med 2002, 30: 2242-2248.CrossRefGoogle Scholar
  2. 2.
    Zouaoui Boudjeltia K, et al.: BMC Biotechnology 2002, 2: 8. 10.1186/1472-6750-2-8CrossRefPubMedGoogle Scholar
  3. 3.
    Vincent JL, et al.: Crit Care Med 2002, 30: S313-S317. 10.1097/00003246-200205001-00022CrossRefPubMedGoogle Scholar

Copyright information

© BioMed Central Ltd 2003

Authors and Affiliations

  • K Zouaoui Boudjeltia
    • 1
  • M Piagnerelli
    • 1
  • E Carlier
    • 2
  • S Jamart
    • 2
  • Ph Cauchie
    • 1
  • M Vanhaeverbeek
    • 1
  1. 1.Experimental Medicine Laboratory, ULB 222 UnitA. Vésale HospitalMontigny-le-TilleulBelgium
  2. 2.Department of Intensive CareA. Vésale HospitalMontigny-le-TilleulBelgium

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