Critical Care

, 18:P217 | Cite as

Surfactant protein A: a candidate predictive biomarker of mortality in acute respiratory distress syndrome in sepsis

  • V Moroz
  • A Kuzovlev
  • A Goloubev
Open Access
Poster presentation
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Keywords

Acute Respiratory Distress Syndrome Septic Patient Surfactant Protein Mediastinitis Acute Respiratory Distress Syndrome Patient 

Introduction

Prediction of mortality in septic acute respiratory distress syndrome (ARDS) is a problem of great significance. The aim of this study was to investigate the role of surfactant protein A (SPA) as a candidate predictive biomarker of mortality in ARDS.

Methods

The observational study in ICU ventilated septic patients with peritonitis (65%), pancreonecrosis (20%) and mediastinitis (15%) was performed in 2010 and 2013. ARDS was diagnosed and staged according to the V.A. Negovsky Research Institute criteria [1, 2] and the Berlin definition. Plasma SPA was measured on ARDS diagnosis (day 0) and days 3 and 5 by the immunoenzyme essay (BioVendor, USA). Patients were treated according to the international guidelines. Data were statistically analyzed by STATISTICA 7.0, ANOVA method, and presented as median and 25th to 75th percentiles, ng/ml; P < 0.05 was considered statistically significant. Areas under the receiver operating curves were calculated.

Results

Eighty-five patients (out of 300 screened) were enrolled in the study according to the inclusion/exclusion criteria. Patients were assigned into groups: ARDS (n = 50, 48 ± 5.7 years old, M/F 35/15, mortality 26%) and noARDS (n = 35, 46 ± 8.7 years old, M/F 30/5, mortality 23%). Groups were comparable in APACHE II scores. In the ARDS group SPA was higher at all points than in the noARDS group (day 0: 32.6, 25 to 75 IQR 18.2 to 60.7 vs. 23.4, 25 to 75 IQR 17.8 to 28.6; day 3: 31.5, 25 to 75 IQR 20.9 to 31.5 vs. 24.6, 25 to 75 IQR 19.7 to 24.6; day 5: 32.5, 25 to 75 IQR 17.3 to 66.4 vs. 22.5, 25 to 75 IQR 13.4 to 29.5, P < 0.05). The plasma SPA was significantly lower in surviving versus dead patients with ARDS (day 0: 20.9, 25 to 75 IQR 13.0 to 35.7 vs. 45.7,25 to 75 IQR 23.5 to 67.9; day 3: 25.5, 25 to 75 IQR 11.8 to 35.5 vs. 45.0, 25 to 75 IQR 29.6 to 68.4; day 5: 24.5, 25 to 75 IQR 11.4 to 33.6 vs. 49.6, 25 to 75 IQR 31.3 to 79.0, P < 0.05). Plasma SPA on day 0 had a good capacity for prediction of mortality in ARDS patients: SPA on day 0 ≥38.8 ng/ml yielded a sensitivity of 65% and specificity of 80% (aUc 0.74; 95% Cl 0.577 to 0.866; P = 0.0026).

Conclusion

Plasma SPA level ≥38.8 ng/ml on the day of ARDS diagnosis is a sensitive and specific candidate biomarker of mortality prediction in ARDS septic patients.

References

  1. 1.
    Kuzovlev A, et al.: Semin Cardiothorac Vasc Anesth. 2010, Emphasis Type="Bold">14: 231-241. 10.1177/1089253210388297CrossRefPubMedGoogle Scholar
  2. 2.
    Kuzovlev A, et al.: Crit Care. 2013, 17: P21800.Google Scholar

Copyright information

© Moroz et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • V Moroz
    • 1
  • A Kuzovlev
    • 1
  • A Goloubev
    • 1
  1. 1.V.A. Negovsky Scientific Research Insitute of General ReanimatologyRAMSMoscowRussia

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