Correlation between arterial lactate and venous lactate in patients with sepsis and septic shock
KeywordsLactate Primary Outcome Septic Shock Emergency Medicine Severe Sepsis
Measurement of arterial lactate (A-LACT) levels has been used to monitor poor tissue perfusion, predicting mortality and guiding resuscitation. Peripheral venous lactate (V-LACT) has been regarded as an unreliable test, but a less invasive approach. We aimed to determine correlation between A-LACT and V-LACT and agreement of both in order to determine the usefulness of V-LACT as a biomarker for assessment in sepsis.
We conduct a prospective, cross-sectional study during June to December 2011 at a university hospital. Septic patients in the ICU were enrolled in this research. Sepsis was defined according to the Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2008. The exclusion criteria were: contraindication for arterial puncture; and denying inform consent. The venous lactate would be sampled at the same point in time as arterial lactate measurement. The correlation and agreement between arterial and venous lactate was the primary outcome.
The arterial lactate and venous lactate levels were strongly correlated in the condition of sepsis or septic shock. Consequently, V-LACT may be used in substitution for A-LACT particularly in lactate levels not higher than 4 mmol/l. However, trending should be generally applied instead of the absolute value.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.