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Arthritis Research & Therapy

, 14:P45 | Cite as

The functions of the post-translational modifications in rheumatoid arthritis

  • Satoko Aratani
  • Naoko Yagishita
  • Teruhisa Kanazawa
  • Fukami Nakajima
  • Yoshihisa Yamano
  • Kusuki Nishioka
  • Toshihiro Nakajima
Poster presentation
  • 748 Downloads

Keywords

Rheumatoid Arthritis Arthritis Cell Proliferation Endoplasmic Reticulum Endoplasmic Reticulum Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Rheumatoid Arthritis (RA) is a chronic inflammatory joint disease and characterized by synovial hyperplasia. We previously cloned an E3 ubiquitin ligase, Synoviolin, as a regulatory factor of cell proliferation [1]. It suggested that endoplasmic reticulum (ER) associated degradation system (ERAD) via Synoviolin has important roles for overgrowth of synoviocytes [2, 3]. Meanwhile, it is known that autoantibodies to citrullinated proteins are specific for RA and good markers for RA. Peptidyl-Arginine Deiminases 4 (PADI4) is identified as the RA-susceptible gene [3]. However functions of citrulinated proteins are unclear. In this study, we hypothesize that the accumulation of citrullinated proteins in RA synoviocytes could associate for ER stress and explore the crosstalk of ubiquitination and citrullination.

References

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Copyright information

© Aratani et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Satoko Aratani
    • 1
  • Naoko Yagishita
    • 2
  • Teruhisa Kanazawa
    • 1
  • Fukami Nakajima
    • 1
  • Yoshihisa Yamano
    • 2
  • Kusuki Nishioka
    • 1
  • Toshihiro Nakajima
    • 1
  1. 1.Institute of Medical ScienceTokyo Medical UniversityTokyoJapan
  2. 2.Institute of Medical ScienceSt. Marianna University School of MedicineKanagawaJapan

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