Successful treatment of tracheal stenosis by rigid bronchoscopy and topical mitomycin C: a case report
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Tracheal stenosis is a known complication of prolonged intubation. It is difficult to treat and traditional surgical approach is associated with significant risk and complications. Recurrent stenosis due to granulation tissue necessitates repeated procedures. We describe a case of short web-like tracheal stenosis (concentric membranous stenosis less than 1 cm in length without associated cartilage damage) managed by a minimally invasive thoracic endoscopic approach. Topical application of Mitomycin C, a potent fibroblast inhibitor reduces granulation tissue formation and prevents recurrence.
KeywordsMitomycin Vocal Cord Granulation Tissue Pterygium Argon Plasma Coagulation
MacEwen first reported endotracheal intubation for anesthesia in 1880 . Lindholm reported injuries to the larynx and trachea after intubation in 1969 . Despite advancement and the use of high volume, low pressure cuffed tubes, tracheal stenosis is not an uncommon complication of endotracheal intubation. In one prospective study of critically ill patients, 11% of patients who were intubated with high volume, low pressure cuffed tubes developed tracheal stenosis . Endotracheal tube causes pressure injury to the glottis and may result in severe commissural scarring that is difficult to treat.
Although there have been reports of successful treatment of tracheal stenosis with steroid regimens [4, 5], the mainstay of treatment for symptomatic lesions is surgical. Various surgical methods have been described including anterior cricotracheal splitting, laryngofissure creation with anterior lumen augmentation, resection or end-to-end anastomosis [6, 7, 8], but they are not without risks. Tracheal reconstruction requires major surgery, with a mortality of about 3% [9, 10]. Rigid bronchoscopy with tracheal dilatation and stenting has been described as some of the treatment methods for less serious lesions . Relapses are relatively frequent, making it the principal long-term problem with this method of treatment [12, 13].
A 30-year-old Malaysian woman who had bilateral upper lobe lung bullae underwent bullectomy in May 2008 for rapidly enlarging bullae causing respiratory compromise. Post-operatively, she was intubated for 6 days. Upon trial of extubation at day 6, she developed shortness of breath. She was re-intubated for another 5 days before extubation was successful and she was discharged 20 days post operatively.
In August 2008, she underwent rigid bronchoscopy using a 12 mm Dumon rigid tracheal tube. This was followed by examination using a small diagnostic flexible bronchoscope via the rigid bronchoscope. A pin hole stenosis of the trachea 3 cm distal to the vocal cords was noted with areas of granulation tissue. We failed to pass the flexible bronchoscope through the stenosis.
There is no significant worsening of the narrowing between 1 month and 4 month. She did not complain of stridor or difficulty in breathing and was back to work.
The optimal treatment of tracheal stenosis remains undefined. Traditionally, tracheal stenosis has been managed by thoracic and othorhinolaryngology surgeons. Endoscopic procedures are usually performed as a bridge to definitive surgical intervention. With the development of interventional pulmonology field in the last 20 years, definitive management of tracheal stenosis using minimally invasive endoscopic methods became a possibility. Collaboration between pulmonologists and surgeons has become increasingly important to help define the best method of management for these patients.
Endoscopic treatment had been shown to be useful, especially in patients who are deemed high risk and too unwell for reconstructive surgery. One of the main drawbacks of endoscopic treatment and surgery is the risk of recurrence of trachea stenosis due to granulation and fibrotic tissue. Studies have shown that most of the recurrence of tracheal stenosis occurs within one to three months after the procedure [12, 14], and use of Mitomycin C has been reported in case studies to reduce the rate of recurrence [13, 15]. Mitomycin C which is isolated from Streptomyces caepitocus acts as a bifunctional alkylating agent cross-linking DNA thereby inhibiting DNA synthesis. Both in vitro and in vivo, Mitomycin C has been proven to be a potent inhibitor of human fibroblasts at concentrations of 0.04 mg/L. It has been used with some success in inhibiting the vigorous granulation response noted after airway injury in animal models and pediatric patients. It has also been used in ophthalmology to treat glaucoma and pterygium.
In this case, we describe a successful management of a short web-like tracheal stenosis via rigid bronchoscopy by interventional pulmonologists with collaboration from othorhinolaryngology surgeons. APC appears to be an effective coagulation method. The use of APC prior to granulation tissue removal allows for easy control of bleeding. The application of cryoprobe to remove granulation tissues also minimizes trauma to the trachea.
Nd:YAP laser would be an interesting alternative to APC for coagulation but it was not available to us at the time. The presence of othorhinolaryngology surgeons during the procedure who have a good knowledge of local airway anatomy allows identification of structures which are distorted by granulation tissues. This prevents the formation of false tract and accidental perforation of the trachea.
In skilled hands, the use of a suspension laryngoscope would be an alternative to rigid bronchoscope in this case. Suspension laryngoscope is ideal if the lesion is either at the vocal cords or just below the vocal cords (subglottic). However, suspension laryngoscope needs to be used with a caveat that there may be a higher risk of irritation and injury to the vocal cords during insertion of surgical instruments to reach the target area which was 3 cm below the vocal cords. Furthermore, the use of a suspension laryngoscope will require jet-ventilation in order to ventilate the patient. The use of rigid bronchoscope allows us to introduce surgical instruments multiple times to the target area with minimal risk of irritating or injuring the vocal cords.
The application of topical Mitomycin C is made possible with the rigid forceps which allows application of sufficient force to the airway mucosa to allow proper application of Mitomycin C. It is important to apply Mitomycin C with sufficient force and contact time to allow Mitomycin C to work. With a contact time of 8 minutes, there is evidence of only minimal granulation tissue or scar tissue after 4 months. Topical Mitomycin C also appears to be safe and there is no detectable myelosuppression.
Topical Mitomycin C is a useful adjunct in the management of short concentric membranous stenosis which does not involve the cartilage. It reduces granulation tissue and prevents recurrence. Further randomized controlled studies are necessary to explore the possibility of this treatment method in the algorithm for the management of tracheal stenosis. This may obviate the need for invasive reconstruction surgery and repetitive procedures.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal
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