Background
Crohn’s Disease (CD) is a chronic inflammatory bowel disease characterised by recurrent intestinal inflammation [1]. Adipose tissue has metabolic and immune functions regulated through the expression of hormones and cytokines [2, 3]. Conventionally, adiposity in CD is believed to reflect disease activity, nutritional status and possibly corticosteroids. Emerging data suggests that adipose tissue may play a more complex immunoregulatory role in CD [4].
Methods
CD patients attending the gastroenterology department were recruited over a 4 week period were invited to partake in this pilot study. The following data was collected: Extent of disease and previous treatments, current disease activity and biometric measurements of adiposity (Body mass index (BMI), waist hip ratio, mid upper arm circumference, skin fold thickness and percentage body fat using biometric impedance analysis (BIA)).
Results
27 patients were recruited in this pilot study. 16 (59%) had BMI >25 and (classified as overweight or obese), 10 had normal BMI and 1 had BMI <18. 32% had body fat stores above normal, 44% within normal range and 24% had low fat stores as measured with BIA. Numbers were too small in this pilot study to establish a relationship between disease pattern and/or activity, those requiring >1 course of steroids in the previous year and those on anti-TNF therapy were more likely to have normal range BMI than the group as a whole. Self reported abdominal pain and decreased well being was highest in patients with an increased BMI.
Conclusions
Obesity rates in the general population are rising [5]. Our study indicates that obesity does present in the CD population. Adipose tissue may be a source of proinflammatory cytokines thus altering the natural history of CD in these patients [6]. Even if there is no impact on disease progression, our findings have important implications for current CD drug and nutritional management.
References
Crohn BB, Ginzburg L, Oppenheimer GD: Regional ileitis – A pathological and clinical entity. JAMA. 1932, 99: 1323-1329.
Kershaw EE, Flier JS: Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004, 89 (6): 2548-
Mohammed AV, Pinknev JH, Coppack SW: Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord. 1998, 22 (12): 1145-1158.
Peyrin-Biroulet L, Chamaillard M, Gonzalez F, Beclin E, Decourcelle C, Antunes L, et al: Mesenteric fat in Crohn’s disease: a pathogenetic hallmark or an innocent bystander. GUT. 2007, 56 (4): 577-583.
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tobak CJ, Flegal KM: Prevalence of overweight and obesity in the united states 1999-2004. JAMA. 2006, 295 (13): 1549-1555.
Curat CA, Miranville A, Sengenès C, Diehl M, Tonus C, Busse R, et al: From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes. 2004, 53 (5): 1285-1292.
Author information
Authors and Affiliations
Rights and permissions
This article is published under an open access license. Please check the 'Copyright Information' section either on this page or in the PDF for details of this license and what re-use is permitted. If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and re-use information, please contact the Rights and Permissions team.
About this article
Cite this article
O’Connor, D., Sexton, G. & McCormack, G. The relationship of adiposity to disease severity in a Crohn's patient cohort. BMC Proc 9 (Suppl 1), A23 (2015). https://doi.org/10.1186/1753-6561-9-S1-A23
Published:
DOI: https://doi.org/10.1186/1753-6561-9-S1-A23