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Retrovirology

, 5:O12 | Cite as

Risk factors for human cytomegalovirus (HCMV) infection in infants born to HIV-1 infected mothers in Thailand

  • Woottichai Khamduang
  • Wasna Sirirungsi
  • Gonzague Jourdain
  • Baptiste Leurent
  • Kenneth McIntosh
  • Karin Pagdi
  • Rosalin Somsamai
  • Surat Sirinontakan
  • Temsiri Hinjiranandana
  • Wanna Ardong
  • Marc Lallemant
  • Nicole Ngo-Giang-Huong
Open Access
Oral presentation
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Keywords

Vaginal Delivery Sexual Transmitted Disease HCMV Infection Uninfected Infant Congenital HCMV Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

In Thailand where virtually all pregnant women are infected with HCMV, about 2% of infants are congenitally infected with HCMV [1]. However, the transmission rate among infants born to HIV-1 infected mothers is not well known. Our objectives were to evaluate HCMV transmission rates in infants born to HIV-1 infected mothers, and to identify maternal and newborn risk factors associated with infant HCMV infection.

Materials and methods

Ninety-seven HIV-1 transmitting mothers were matched on maternal plasma HIV-1 RNA before zidovudine prophylaxis initiation with 194 non-transmitting mothers enrolled in PHPT-1 [2], an HIV prevention trial in Thailand. Infant HCMV infection was assessed by anti-HCMV IgM and/or HCMV DNA within 6 months of age and by IgG serology at 18 months. Congenital HCMV infection was defined as the presence of HCMV IgM and/or a positive DNA PCR within 10 days of life. Univariate odds ratio (95% confidence intervals) were calculated for potential risk factors among maternal (age, HIV and immunological stage, pregnancy history, pregnancy complications, induction of labor, mode of delivery, past/present sexual transmitted diseases, CD4/CD8 T-lymphocyte counts) and infant characteristics (HIV status, sex, prematurity and birth weight). Adjusted odds ratios were calculated using logistic regression with stepwise selection of variables with less than 0.20 p value association.

Results

The prevalence of congenital HCMV infection was 16% (10/62) in HIV-1 infected infants and 5% (5/105) in uninfected infants, p=0.013. The prevalence of HCMV infection by 18 months of age was 83% (62/75) in HIV-1 infected infants and 62% (112/182) in uninfected infants, p=0.001. Upon univariate analysis, among the maternal factors, only vaginal delivery was associated with HCMV infection in infants (OR: 2.5; 95%CI: 1.3-4.7). Among infants' factors, HIV infection (OR: 3.3; 95%CI: 1.7-7.0) and prematurity (OR: 3.5; 95%CI: 1.0-18.8) were associated with HCMV. Upon multivariate analysis only vaginal delivery (OR: 2.5; 95%CI: 1.3-4.5) and infant HIV infection (OR: 3.3; 95%CI: 1.7-6.4) remained independently associated with HCMV infection in infants.

Conclusions

Infant HIV infection and vaginal delivery are the main risk factors for HCMV infection in children born to HIV-1 infected mothers. The clinical consequences of congenital and postnatal HCMV infection on HIV disease progression need to be assessed.

Notes

Acknowledgements

This work was supported by Fogarty International Research Collaboration Award (FIRCA, NIH, USA), Grant number: R03TW01346-01.

References

  1. 1.
    Pholampaisathit S, Lausoontornsiri W: Rate of congenital cytomegalovirus infection: 1996 2000. Bulletin of the department of medical services. 2001, 26: 200-205.Google Scholar
  2. 2.
    Lallemant M, Jourdain G, Le Coeur S, Kim S, Koetsawang S, Comeau AM, Phoolcharoen W, Essex M, McIntosh K, Vithayasai V: A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med. 2000, 343: 982-991. 10.1056/NEJM200010053431401.CrossRefPubMedGoogle Scholar

Copyright information

© Khamduang et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • Woottichai Khamduang
    • 1
    • 2
  • Wasna Sirirungsi
    • 2
  • Gonzague Jourdain
    • 1
    • 3
  • Baptiste Leurent
    • 1
  • Kenneth McIntosh
    • 4
  • Karin Pagdi
    • 5
  • Rosalin Somsamai
    • 5
  • Surat Sirinontakan
    • 6
  • Temsiri Hinjiranandana
    • 7
  • Wanna Ardong
    • 8
  • Marc Lallemant
    • 1
    • 3
  • Nicole Ngo-Giang-Huong
    • 1
    • 3
  1. 1.Institut de Recherche pour le Developpement UMI 174/Programs for HIV Prevention and Treatment (PHPT)Chiang MaiThailand
  2. 2.Faculty of Associated Medical SciencesChiang Mai UniversityChiang MaiThailand
  3. 3.Harvard School of Public HealthHarvard UniversityBostonUSA
  4. 4.Harvard Medical SchoolHarvard UniversityBostonUSA
  5. 5.Lamphun HospitalLamphunThailand
  6. 6.Health Promotion Hospital Regional Center IBangkokThailand
  7. 7.Somdej Pranangchao Sirikit HospitalChonburiThailand
  8. 8.Buddhachinaraj HospitalPitsanulokeThailand

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