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Evolution of gray zone after acute myocardial infarction: Influence of microvascular obstruction

  • Nilesh R Ghugre
  • Mohammad I Zia
  • Perry Radau
  • John J Graham
  • Kim Connelly
  • Alexander J Dick
  • Graham A Wright
Open Access
Poster presentation

Keywords

Percutaneous Coronary Intervention Acute Myocardial Infarction Acute Myocardial Infarction Primary Percutaneous Coronary Intervention Gray Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

The presence of ischemia-induced microvascular obstruction (MVO) despite successful coronary revascularization, has been associated with poor functional recovery and adverse left ventricular remodeling after acute myocardial infarction (AMI). Additionally, the extent of the infarct gray zone is a strong independent predictor of post-AMI mortality. However, the evolution of gray zone after AMI has not been investigated and its relationship with MVO in terms of risk stratification is unknown.

Purpose

To characterize the evolution of gray zone and determine its correlation with the presence of MVO during infarct healing in patients treated with primary percutaneous coronary intervention (PCI).

Methods

Patients were enrolled post-PCI and underwent MRI examination on a 1.5T scanner (GE Signa Excite) at day 2, week 4 and month 6 following AMI. Cardiac function [Ejection fraction (EF), End-diastolic volume (EDV)] was evaluated using a steady-state-free-precession (SSFP) sequence in cine mode. A T1-weighted IR-GRE sequence was used for delayed-hyperenhancement (DHE) of infarcted myocardium. Infarct core (IC) and gray zone (GZ) volumes were quantified using the full-width-half-maximum technique as previously described; both quantities were expressed as a percentage of myocardial volume. MVO’s were manually traced and included in the infarct core calculation.

Results

Ten patients who completed MRI exams at all three time points were included in the study [mean age: 59.7±11 years; 9 males, 1 female; 4 right coronary artery and 2 left circumflex artery PCI; MVO was identified in 4 patients]. Figure 1 shows DHE images from representative patients in the MVO and non-MVO groups while Tables 1, 2, 3 summarize the corresponding quantities measured. Note that the following findings were significant: (a) infarct core was reduced in all patients by month 6; (b) MVO was resolved by week 4; (b) gray zone size relative to infarct size, GZr = 100*GZ/(GZ+IC) increased in the MVO group at month 6 while it remained stable in the non-MVO group; (d) EF was reduced in the MVO group compared to the non-MVO at all time points (p<0.05). The percent change in GZr (ΔGZr) at week 4 and month 6, relative to day 2 is shown in Figure 2.
Figure 1

Delayed-enhanced short-axis slices from two representative patients in the MVO and non-MVO groups imaged at three different time points post AMI. Color coding identifies three regions: Infarct core (green), gray zone (yellow) and microvascular obstruction (red).

Table 1

All patients (N=10)

 

Day 2

Week 4

Month 6

GZ (%)

7.8±3.5

7.4±6.0

7.2±5.0

IC (%)

18.5±11.6

12.2±8.1 *

11.5±8.1 *

MVO (%)

3.5±5.1

0.2±0.3

0.2±0.4

EF (%)

47.4±7.1

49.8±7.8

51.5±11.1

EDV (ml)

123.2±30.3

143.9±33.0

117.0±23.8

GZr (%)

31.4±7.8

37.4±17.0

38.1±11.7

Values have been expressed as mean±standard deviation.

p-values were measured with respect to day 2 measurements by paired Students t-test

* p<0.01

Table 2

non-MVO patients (N=6)

 

Day 2

Week 4

Month 6

GZ (%)

6.6±3.1

4.4±2.3 **

4.5±2.7

IC (%)

11.8±4.5

8.9±6.6

7.5±5.3 **

MVO (%)

0

0

0

EF (%)

50.8±7.3

53.3±8.3

57.5±7.1

EDV (ml)

134.6±27.4

135.0±22.9

117.6±23.7

GZr (%)

34.5±5.7

30.3±11.8

33.6±10.2

Values have been expressed as mean±standard deviation.

p-values were measured with respect to day 2 measurements by paired Students t-test

** p<0.05

Table 3

MVO patients (N=4)

 

Day 2

Week 4

Month 6

GZ (%)

9.7±3.6

12.0±7.2

11.3±5.0

IC (%)

28.5±12.0

17.2±8.2 **

17.5±8.5 **

MVO (%)

8.7±4.2

0.4±0.5 **

0.4±0.6 **

EF (%)

42.2±3.0

44.6±3.0

42.3±10.0

EDV (ml)

106.1±29.1

157.3±44.7 *

116.2±27.6 *

GZr (%)

26.1±8.7

39.4±18.5

38.9±10.7 **

Values have been expressed as mean±standard deviation.

p-values were measured with respect to day 2 measurements by paired Students t-test

* p<0.01, ** p<0.05

Figure 2

Plot demonstrates the change in GZr at two time points (t) i.e. week 4 and month 6 relative to the initial measurement at day 2. Error bars indicate standard error.

Conclusions

The increase in infarct gray zone or arrhythmogenic substrate may be one of the possible mechanisms responsible for adverse remodeling and poor clinical prognosis in patients with MVO. Monitoring the early evolution of gray zone in the high-risk patients could also potentially help identify the optimal timing and candidates for placement of implantable cardioverter-defibrillator.

Copyright information

© Ghugre et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Nilesh R Ghugre
    • 1
  • Mohammad I Zia
    • 1
  • Perry Radau
    • 1
  • John J Graham
    • 2
  • Kim Connelly
    • 2
  • Alexander J Dick
    • 3
  • Graham A Wright
    • 1
  1. 1.Sunnybrook Health Sciences CentreTorontoCanada
  2. 2.St. Michael's HospitalTorontoCanada
  3. 3.University of Ottawa Heart InstituteOttawaCanada

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