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1054 Noninvasive Qp/Qs ratio measurement with phase-contrast cine MRI in patients with atrial septal defect: comparison with heart catheterization

  • Amedeo Chiribiri
  • Laura Rizzo
  • Maria Cristina Marocco
  • Marco Allasia
  • Rodolfo Bonamini
  • Fulvio Orzan
  • Cesare Fava
  • Gian Paolo Trevi
Open Access
Meeting abstract
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Keywords

Public Health Blood Flow Regression Analysis Correlation Analysis Method Comparison 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

Blood flow can be quantified noninvasively by phase-contrast cine MRI (PC-MRI) in adults. Little is known about the accuracy of this measurement in patients with known atrial septal defect.

Purpose

Aim of the study was to compare the results of PC-Mri with heart catheterization

Methods

In 25 patients with a type-II atrial septal defect, blood flow rate in the great vessels was determined by 1 Tesla PC-MRI and the ratio of pulmonary to aortic flow (Qp/Qs) was compared with Qp/Qs by oximetry requiring heart catheterization, performed before of an attempt of percutaneous closure of the defect.

Results

The interval between measurements was 11 ± 18 days (range 1–78 days). Mean Qp was 9.2 ± 3.3 l/min with PC-MRI, and 8.6 ± 4 l/min with catheterization (p = 0.57). Mean Qs was 4.8 ± 1.6 l/min with PC-MRI, and 4.5 ± 1.3 l/min with catheterization (p = 0.46). Qp/Qs ratio was 1.99 ± 0.72 with PC-MRI, and 1.96 ± 0.96 with catheterization (p = 0.92).

The correlation analysis showed a good overlap between measurements (Qp: r = 0.65, p = 0.0004; Qs: r = 0.64, p = 0.0005; Qp/Qs ratio: r = 0.68, p = 0.0002), also confirmed by regression analysis (R2 = 0.42, p < 0.001 for Qp; R2 = 0.41, p = 0.001 for QS; R2 = 0.46, p < 0.001 for Qp/Qs ratio), and by the Bland-Altman statistical analysis for method comparison (see Figure 1). The interobserver variability was low.

Figure 1

Conclusion

Determination of Qp/Qs ratio by PC-MRI is quick, safe, and reliable compared with oximetry. This noninvasive method could be used to quantify the interatrial shunt in patients with known atrial septal type-II defect, in order to demonstrate hemodinamic importance of the defect, and to reduce the need for time-consuming diagnostic heart catheterization.

Copyright information

© Chiribiri et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • Amedeo Chiribiri
    • 1
  • Laura Rizzo
    • 1
  • Maria Cristina Marocco
    • 1
  • Marco Allasia
    • 1
  • Rodolfo Bonamini
    • 1
  • Fulvio Orzan
    • 1
  • Cesare Fava
    • 1
  • Gian Paolo Trevi
    • 1
  1. 1.University of Torino, ItalyTorinoItaly

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