I Open image in new window B, NF- Open image in new window B Regulation Model: Simulation Analysis of Small Number of Molecules

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Research Article
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Abstract

The regulation of I Open image in new window B, NF- Open image in new window B is of foremost interest in biology as the transcription factor NF- Open image in new window B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of I Open image in new window B, NF- Open image in new window B mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF- Open image in new window B oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.

Keywords

Transcription Factor Target Gene Cell Population Reaction System Individual Cell 

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Copyright information

© Anamika Sarkar et al. 2007

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Anamika Sarkar
    • 1
    • 2
  • Marina Meila
    • 3
  • Robert B Franza
    • 1
  1. 1.Bioengineering Department, Cell Systems InitiativeUniversity of WashingtonSeattleUSA
  2. 2.Department of Pharmacology and Systems TherapeuticsMount Sinai School of MedicineNew YorkUSA
  3. 3.Statistics DepartmentUniversity of WashingtonSeattleUSA

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