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Supercritical fluid encapsulation of acizol into aliphatic polyether microparticles

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Abstract

Encapsulation of pharmaceutical grade acizol (Acizol® pharmaceutical substance) into bioresorbable D,L-polylactide and polylactoglycolide microparticles using supercritical carbon dioxide has been studied. An effective way for formation of polymer fine powders (mean particle size of about 10–20 µm) containing up to 20 wt % of the bioactive component without any organic solvent used has been suggested. Raman spectroscopy with spatial resolution was employed to analyze the distribution of acizol throughout the volume of the individual polymer microparticles and to study the kinetics of its release into saline. The rapid release (40–80% of the total amount of the encapsulated substance) from the samples under study was observed during the first hour, and then it was followed by a gradual, almost linear release between the 4th and 14th days of the experiment, with the total release continuing up to 100%.

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References

  1. Russian Therapeutic Reference Book, Ed. by A. G. Chuchalin (GEOTAR-Media, Moscow, 2005) [in Russian].

  2. P. I. Sidorov, I. G. Mosyagin, and A. S. Sarychev, Medicine of Catastrophes (Academia, Moscow, 2012) [in Russian].

    Google Scholar 

  3. RF Patent No. 2070201 (1978).

  4. Kh. Kh. Babaniyazov, L. V. Baikalova, V. K. Stankevich, V. A. Barinov, A. R. Ermakov, S. P. Nechiporenko, and B. A. Trofimov, in New Drugs: Achievements and Perspectives (Gilem, Ufa, 2005), p. 183 [in Russian].

    Google Scholar 

  5. RF Patent No. 2247558 (2005).

  6. V. I. Sevast’yanov, L. A. Salomatina, E. G. Kuznetsova, M. V. Seregina, and Yu. B. Basok, Perspekt. Mater., No. 6, 55 (2008).

    Google Scholar 

  7. S. P. Cape, J. A. Villa, E. T. S. Huang, T. H. Yang, J. F. Carpenter, and R. E. Sievers, Pharmaceut. Res. 25, 1967 (2008).

    Article  CAS  Google Scholar 

  8. E. N. Antonov and V. K. Popov, Russ. J. Phys. Chem. B 8, 980 (2014).

    Article  CAS  Google Scholar 

  9. S. M. Howdle, M. S. Watson, M. J. Whitaker, V. K. Popov, M. C. Davies, F. S. Mandel, J. D. Wang, and K. M. Shakesheff, Chem. Commun., 109 (2001).

    Google Scholar 

  10. E. N. Antonov, S. E. Bogorodskii, B. M. Feldman, E. A. Markvicheva, L. D. Rumsh, and V. K. Popov, Sverkhkrit. Fluidy: Teor. Prakt. 3 (1), 34 (2008).

    Google Scholar 

  11. S. E. Bogorodskii, L. I. Krotova, S. A. Minaeva, G. V. Mishakov, V. G. Popov, Yu. B. Basok, and V. I. Sevast’yanov, Perspekt. Mater., No. 1, 23 (2013).

    Google Scholar 

  12. M. Vert, S. M. Li, G. Spenlehauer, and P. Guerin, J. Mater. Sci.: Mater. Med. 3, 432 (1992).

    CAS  Google Scholar 

  13. E. Reverchon, R. Adami, S. Cardea, and G. D. Porta, J. Supercrit. Fluids 47, 484 (2009).

    Article  CAS  Google Scholar 

  14. H. Tai, V. K. Popov, K. M. Shakesheff, and S. M. Howdle, Biochem. Soc. Trans. 35, 516 (2007).

    Article  CAS  Google Scholar 

  15. E. N. Antonov, I. V. Vakhrushev, S. A. Minaeva, and V. K. Popov, Perspekt. Mater., No. 6, 44 (2012).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Laser and Information Technologies, Russian Academy of Sciences, Moscow, Russia

    S. E. Bogorodski, L. I. Krotova, S. A. Minaeva & V. K. Popov

  2. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russia

    S. V. Kursakov & V. I. Sevast’yanov

Authors
  1. S. E. Bogorodski
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  2. L. I. Krotova
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  3. S. V. Kursakov
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  4. S. A. Minaeva
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  5. V. K. Popov
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  6. V. I. Sevast’yanov
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Corresponding author

Correspondence to V. K. Popov.

Additional information

Original Russian Text © S.E. Bogorodski, L.I. Krotova, S.V. Kursakov, S.A. Minaeva, V.K. Popov, V.I. Sevast’yanov, 2014, published in Sverkhkriticheskie Flyuidy: Teoriya i Praktika, 2014, Vol. 9, No. 2, pp. 64–73.

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Bogorodski, S.E., Krotova, L.I., Kursakov, S.V. et al. Supercritical fluid encapsulation of acizol into aliphatic polyether microparticles. Russ. J. Phys. Chem. B 9, 1011–1017 (2015). https://doi.org/10.1134/S1990793115070052

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  • DOI: https://doi.org/10.1134/S1990793115070052

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